CD209 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD209 at tissue level.

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0006897Biological processendocytosis
GO_0044419Biological processbiological process involved in interspecies interaction between organisms
GO_0075733Biological processintracellular transport of virus
GO_0045087Biological processinnate immune response
GO_0042129Biological processregulation of T cell proliferation
GO_1903902Biological processpositive regulation of viral life cycle
GO_0097323Biological processB cell adhesion
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0046718Biological processsymbiont entry into host cell
GO_0035556Biological processintracellular signal transduction
GO_0046968Biological processpeptide antigen transport
GO_0019882Biological processantigen processing and presentation
GO_0019062Biological processvirion attachment to host cell
GO_0009988Biological processcell-cell recognition
GO_0019079Biological processviral genome replication
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0043657Cellular componenthost cell
GO_0005537Molecular functionD-mannose binding
GO_0030246Molecular functioncarbohydrate binding
GO_0001618Molecular functionvirus receptor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0046790Molecular functionvirion binding
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameCD209
Protein nameCD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)
CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1)
SynonymshCG_22558
CLEC4L
DescriptionFUNCTION: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. .; FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Dengue virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Measles virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus A. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS-CoV. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Lassa virus . Acts as an attachment receptor for Marburg virusn. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. .; FUNCTION: (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA . Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule . .

FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. .

FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. .

FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. .

AccessionsENST00000593660.5
X6RB12
ENST00000602261.5 [Q9NNX6-3]
ENST00000204801.12 [Q9NNX6-7]
ENST00000394161.9 [Q9NNX6-4]
ENST00000315599.12 [Q9NNX6-1]
ENST00000394173.8
M0QZG5
Q9NNX6
ENST00000315591.12 [Q9NNX6-6]
M0R0P0
ENST00000593821.5
ENST00000354397.10 [Q9NNX6-2]
ENST00000601951.5 [Q9NNX6-10]
ENST00000601256.1 [Q9NNX6-12]