ASGR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0044419Biological processbiological process involved in interspecies interaction between organisms
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0042806Molecular functionfucose binding
GO_0005537Molecular functionD-mannose binding
GO_0004873Molecular functionasialoglycoprotein receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASGR2
Protein nameAsialoglycoprotein receptor 2
Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
Asialoglycoprotein receptor 2 (HBxAg-binding protein)
SynonymsCLEC4H2
HBXBP
DescriptionFUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

AccessionsENST00000691900.1
ENST00000254850.11 [P07307-3]
Q7Z4G9
P07307
ENST00000446679.6 [P07307-2]
ENST00000355035.9 [P07307-1]
I3L1H2
ENST00000574868.1