Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 99% | 4373.54 | 1435 / 1445 | 100% | 291.17 | 183 / 183 |
| stomach | 99% | 5983.95 | 355 / 359 | 98% | 170.85 | 281 / 286 |
| pancreas | 100% | 5602.66 | 328 / 328 | 96% | 134.83 | 171 / 178 |
| intestine | 96% | 6244.45 | 928 / 966 | 99% | 182.56 | 521 / 527 |
| kidney | 100% | 6120.99 | 89 / 89 | 93% | 96.09 | 836 / 901 |
| prostate | 100% | 5580.97 | 244 / 245 | 93% | 60.83 | 467 / 502 |
| thymus | 100% | 4188.96 | 651 / 653 | 90% | 50.31 | 543 / 605 |
| uterus | 100% | 7234.12 | 170 / 170 | 86% | 119.34 | 393 / 459 |
| breast | 100% | 10314.58 | 459 / 459 | 82% | 68.01 | 922 / 1118 |
| bladder | 95% | 5635.67 | 20 / 21 | 85% | 116.76 | 426 / 504 |
| lung | 98% | 5537.52 | 569 / 578 | 80% | 116.59 | 920 / 1155 |
| brain | 78% | 1984.44 | 2071 / 2642 | 78% | 35.21 | 548 / 705 |
| skin | 78% | 5458.69 | 1406 / 1809 | 72% | 71.81 | 340 / 472 |
| adipose | 100% | 8847.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5333.69 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 222.60 | 44 / 45 |
| ovary | 48% | 1094.00 | 87 / 180 | 49% | 19.81 | 211 / 430 |
| heart | 95% | 3149.55 | 820 / 861 | 0% | 0 | 0 / 0 |
| muscle | 87% | 2017.75 | 700 / 803 | 0% | 0 | 0 / 0 |
| liver | 27% | 435.96 | 61 / 226 | 51% | 23.55 | 206 / 406 |
| blood vessel | 69% | 2128.33 | 918 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 19% | 323.06 | 48 / 258 | 43% | 23.83 | 100 / 230 |
| peripheral blood | 11% | 204.30 | 106 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0031589 | Biological process | cell-substrate adhesion |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0010811 | Biological process | positive regulation of cell-substrate adhesion |
| GO_0035878 | Biological process | nail development |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0050900 | Biological process | leukocyte migration |
| GO_0007044 | Biological process | cell-substrate junction assembly |
| GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
| GO_0043589 | Biological process | skin morphogenesis |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0071407 | Biological process | cellular response to organic cyclic compound |
| GO_0010668 | Biological process | ectodermal cell differentiation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0034676 | Cellular component | integrin alpha6-beta4 complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008305 | Cellular component | integrin complex |
| GO_0034675 | Cellular component | integrin alpha6-beta1 complex |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0009986 | Cellular component | cell surface |
| GO_0030175 | Cellular component | filopodium |
| GO_0005912 | Cellular component | adherens junction |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0031994 | Molecular function | insulin-like growth factor I binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0043236 | Molecular function | laminin binding |
| GO_0038132 | Molecular function | neuregulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ITGA6 |
| Protein name | Integrin subunit alpha 6 Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] |
| Synonyms | |
| Description | FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling . ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling . . |
| Accessions | ENST00000442250.6 [P23229-1] ENST00000416789.1 A0A8C8KBL6 ENST00000409532.5 [P23229-7] ENST00000412899.5 ENST00000684293.1 [P23229-2] ENST00000264107.12 ENST00000409080.6 [P23229-3] P23229 H7BZ97 ENST00000458358.5 [P23229-5] C9JXX7 |
