ITGA5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	29% ± 10%	Explore
endothelial cell of lymphatic vessel	14 studies	25% ± 8%	Explore
capillary endothelial cell	13 studies	28% ± 9%	Explore
vein endothelial cell	13 studies	36% ± 15%	Explore
endothelial cell of vascular tree	13 studies	27% ± 10%	Explore
endothelial cell of artery	12 studies	39% ± 12%	Explore
classical monocyte	11 studies	25% ± 8%	Explore
fibroblast	8 studies	23% ± 7%	Explore
smooth muscle cell	6 studies	21% ± 7%	Explore
macrophage	6 studies	17% ± 2%	Explore
myeloid cell	5 studies	25% ± 7%	Explore
conventional dendritic cell	4 studies	27% ± 8%	Explore
monocyte	3 studies	21% ± 6%	Explore
pericyte	3 studies	28% ± 6%	Explore
extravillous trophoblast	3 studies	65% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
placenta	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	21307.97	576 / 578	98%	62.39	1128 / 1155
breast	96%	12439.08	442 / 459	98%	53.75	1099 / 1118
bladder	100%	70789.62	21 / 21	88%	53.85	442 / 504
esophagus	86%	25264.21	1245 / 1445	98%	79.65	180 / 183
prostate	92%	26468.51	225 / 245	92%	36.81	462 / 502
uterus	96%	17077.39	163 / 170	87%	68.89	399 / 459
thymus	86%	7615.27	560 / 653	94%	25.78	566 / 605
intestine	89%	40823.50	863 / 966	88%	40.74	465 / 527
adrenal gland	84%	6858.26	218 / 258	82%	39.77	189 / 230
stomach	69%	12605.09	249 / 359	91%	46.18	259 / 286
skin	72%	19028.69	1294 / 1809	87%	42.56	412 / 472
ovary	64%	5707.94	115 / 180	77%	23.82	329 / 430
liver	31%	2389.46	70 / 226	96%	51.51	390 / 406
kidney	29%	1900.61	26 / 89	84%	63.98	756 / 901
blood vessel	100%	81408.61	1333 / 1335	0%	0	0 / 0
pancreas	2%	186.39	8 / 328	97%	79.51	173 / 178
adipose	99%	18538.66	1196 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	50.89	41 / 45
heart	82%	10755.22	705 / 861	0%	0	0 / 0
peripheral blood	71%	7908.03	660 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	19.11	18 / 29
brain	1%	80.67	24 / 2642	48%	16.83	337 / 705
eye	0%	0	0 / 0	46%	8.52	37 / 80
muscle	14%	1013.31	114 / 803	0%	0	0 / 0
spleen	5%	350.52	13 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0023035	Biological process	CD40 signaling pathway
GO_0001525	Biological process	angiogenesis
GO_0031589	Biological process	cell-substrate adhesion
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0033631	Biological process	cell-cell adhesion mediated by integrin
GO_0007160	Biological process	cell-matrix adhesion
GO_0010811	Biological process	positive regulation of cell-substrate adhesion
GO_0035987	Biological process	endodermal cell differentiation
GO_1903672	Biological process	positive regulation of sprouting angiogenesis
GO_0007155	Biological process	cell adhesion
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_2000811	Biological process	negative regulation of anoikis
GO_0007565	Biological process	female pregnancy
GO_0046718	Biological process	symbiont entry into host cell
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0030335	Biological process	positive regulation of cell migration
GO_0007044	Biological process	cell-substrate junction assembly
GO_0007613	Biological process	memory
GO_0030949	Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0098609	Biological process	cell-cell adhesion
GO_0035313	Biological process	wound healing, spreading of epidermal cells
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0001726	Cellular component	ruffle
GO_0032587	Cellular component	ruffle membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0034674	Cellular component	integrin alpha5-beta1 complex
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0008305	Cellular component	integrin complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0009986	Cellular component	cell surface
GO_0071062	Cellular component	alphav-beta3 integrin-vitronectin complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045211	Cellular component	postsynaptic membrane
GO_0005161	Molecular function	platelet-derived growth factor receptor binding
GO_0005154	Molecular function	epidermal growth factor receptor binding
GO_0001618	Molecular function	virus receptor activity
GO_0043184	Molecular function	vascular endothelial growth factor receptor 2 binding
GO_0005178	Molecular function	integrin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGA5
Protein name	Integrin subunit alpha 5 (cDNA FLJ50382, moderately similar to Integrin alpha-5) Integrin subunit alpha 5 Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Synonyms	FNRA
Description	FUNCTION: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 . ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 . ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling . ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling . .; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. .; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. .
Accessions	ENST00000435631.6 H0YIV7 ENST00000553071.1 ENST00000547197.1 H0YHL9 ENST00000293379.9 B4E3F4 P08648

ITGA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review