KCNJ3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	11 studies	65% ± 24%	Explore
GABAergic neuron	9 studies	61% ± 24%	Explore
interneuron	6 studies	56% ± 31%	Explore
retina horizontal cell	6 studies	53% ± 20%	Explore
oligodendrocyte precursor cell	5 studies	21% ± 6%	Explore
neuron	4 studies	33% ± 9%	Explore
granule cell	4 studies	64% ± 19%	Explore
astrocyte	4 studies	35% ± 15%	Explore
endothelial cell	3 studies	42% ± 10%	Explore
epithelial cell	3 studies	24% ± 5%	Explore
retinal ganglion cell	3 studies	33% ± 20%	Explore
GABAergic amacrine cell	3 studies	32% ± 16%	Explore
glycinergic amacrine cell	3 studies	37% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	39% ± 24%	Explore
kidney	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	97%	589.53	86 / 89	80%	14.57	717 / 901
brain	81%	2528.07	2152 / 2642	66%	7.46	465 / 705
blood vessel	88%	746.20	1175 / 1335	0%	0	0 / 0
prostate	54%	356.03	133 / 245	32%	2.79	163 / 502
pancreas	23%	56.20	74 / 328	34%	3.28	61 / 178
liver	23%	69.65	52 / 226	32%	2.35	130 / 406
heart	55%	1324.95	473 / 861	0%	0	0 / 0
intestine	18%	92.06	170 / 966	35%	2.54	186 / 527
esophagus	26%	92.35	377 / 1445	23%	2.72	43 / 183
breast	2%	6.78	8 / 459	43%	46.48	484 / 1118
adrenal gland	6%	21.24	16 / 258	32%	2.86	73 / 230
stomach	5%	11.78	19 / 359	30%	2.86	85 / 286
bladder	19%	77.81	4 / 21	11%	0.62	54 / 504
spleen	12%	32.08	30 / 241	0%	0	0 / 0
uterus	6%	37.43	11 / 170	6%	0.34	26 / 459
lung	1%	3.63	3 / 578	8%	0.83	94 / 1155
ovary	4%	11.03	7 / 180	1%	0.02	3 / 430
lymph node	0%	0	0 / 0	3%	0.18	1 / 29
thymus	1%	5.66	5 / 653	3%	0.22	16 / 605
adipose	1%	3.74	18 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.07	1 / 80
skin	0%	0.23	2 / 1809	1%	0.04	5 / 472
muscle	0%	1.69	4 / 803	0%	0	0 / 0
peripheral blood	0%	0.61	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006813	Biological process	potassium ion transport
GO_0098914	Biological process	membrane repolarization during atrial cardiac muscle cell action potential
GO_0051602	Biological process	response to electrical stimulus
GO_0098915	Biological process	membrane repolarization during ventricular cardiac muscle cell action potential
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0099625	Biological process	ventricular cardiac muscle cell membrane repolarization
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_0034765	Biological process	regulation of monoatomic ion transmembrane transport
GO_0086091	Biological process	regulation of heart rate by cardiac conduction
GO_1990573	Biological process	potassium ion import across plasma membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0030315	Cellular component	T-tubule
GO_0098688	Cellular component	parallel fiber to Purkinje cell synapse
GO_1990566	Cellular component	I(KACh) inward rectifier potassium channel complex
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_1902282	Molecular function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO_0015467	Molecular function	G-protein activated inward rectifier potassium channel activity
GO_0086089	Molecular function	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO_0099508	Molecular function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005242	Molecular function	inward rectifier potassium channel activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KCNJ3
Protein name	Potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) G protein-activated inward rectifier potassium channel 1 (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
Synonyms	GIRK1
Description	FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. . FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. . FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. .
Accessions	ENST00000651198.1 D2XBF0 P48549 D2X9V0 Q53R59 A0A494C0M7 ENST00000295101.3 [P48549-1] ENST00000544049.2 [P48549-2]

KCNJ3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review