GRIA2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	16 studies	50% ± 20%	Explore
oligodendrocyte	16 studies	45% ± 15%	Explore
oligodendrocyte precursor cell	16 studies	81% ± 13%	Explore
glutamatergic neuron	13 studies	80% ± 17%	Explore
GABAergic neuron	11 studies	73% ± 21%	Explore
amacrine cell	8 studies	52% ± 10%	Explore
interneuron	7 studies	69% ± 25%	Explore
microglial cell	7 studies	28% ± 16%	Explore
retinal ganglion cell	7 studies	59% ± 16%	Explore
retina horizontal cell	6 studies	43% ± 10%	Explore
neuron	5 studies	62% ± 11%	Explore
endothelial cell	5 studies	50% ± 25%	Explore
OFF-bipolar cell	5 studies	46% ± 19%	Explore
retinal bipolar neuron	4 studies	43% ± 6%	Explore
granule cell	4 studies	72% ± 13%	Explore
ON-bipolar cell	4 studies	40% ± 11%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	71% ± 8%	Explore
GABAergic interneuron	3 studies	85% ± 5%	Explore
GABAergic amacrine cell	3 studies	63% ± 15%	Explore
glycinergic amacrine cell	3 studies	58% ± 9%	Explore
rod bipolar cell	3 studies	54% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	59% ± 20%	Explore
eye	6 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	10286.94	2638 / 2642	97%	75.15	685 / 705
adrenal gland	7%	94.84	18 / 258	65%	16.41	150 / 230
uterus	56%	1577.64	96 / 170	8%	2.38	36 / 459
blood vessel	33%	1069.40	438 / 1335	0%	0	0 / 0
breast	5%	107.53	25 / 459	21%	10.53	233 / 1118
skin	10%	140.69	185 / 1809	7%	1.47	34 / 472
ovary	5%	71.99	9 / 180	10%	0.70	41 / 430
stomach	10%	150.45	35 / 359	1%	0.03	2 / 286
pancreas	0%	3.92	1 / 328	7%	0.71	13 / 178
esophagus	4%	76.63	64 / 1445	1%	0.07	2 / 183
kidney	0%	0	0 / 89	1%	0.21	12 / 901
eye	0%	0	0 / 0	1%	0.04	1 / 80
adipose	1%	31.96	12 / 1204	0%	0	0 / 0
prostate	0%	6.78	1 / 245	0%	0.02	2 / 502
liver	0%	0	0 / 226	1%	0.04	3 / 406
bladder	0%	0	0 / 21	1%	0.11	3 / 504
intestine	0%	0	0 / 966	0%	0.04	2 / 527
lung	0%	0	0 / 578	0%	0.06	4 / 1155
thymus	0%	0	0 / 653	0%	0.01	2 / 605
muscle	0%	1.77	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0007165	Biological process	signal transduction
GO_0035235	Biological process	ionotropic glutamate receptor signaling pathway
GO_0007268	Biological process	chemical synaptic transmission
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098843	Cellular component	postsynaptic endocytic zone
GO_0098839	Cellular component	postsynaptic density membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0032281	Cellular component	AMPA glutamate receptor complex
GO_0098794	Cellular component	postsynapse
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0032279	Cellular component	asymmetric synapse
GO_0014069	Cellular component	postsynaptic density
GO_0060076	Cellular component	excitatory synapse
GO_0099094	Molecular function	ligand-gated monoatomic cation channel activity
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0001540	Molecular function	amyloid-beta binding
GO_0004970	Molecular function	glutamate-gated receptor activity
GO_0004971	Molecular function	AMPA glutamate receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GRIA2
Protein name	Glutamate receptor Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2) Glutamate ionotropic receptor AMPA type subunit 2 AMPA-selective glutamate receptor 2
Synonyms	GLUR2
Description	FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system . It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .
Accessions	ENST00000703759.1 P42262 ENST00000507898.5 [P42262-4] ENST00000703719.1 ENST00000323661.10 ENST00000703756.1 ENST00000645636.1 [P42262-3] A0A994J3U8 A0A994J3V2 G8HBB1 ENST00000703717.1 ENST00000703765.1 [P42262-4] ENST00000703769.1 D6R9Z0 ENST00000510854.1 ENST00000703763.1 A0A994J6Y1 ENST00000296526.12 [P42262-2] A0A994J6K1 ENST00000703750.1 A0A994J6Z5 A0A994J6J5 ENST00000703757.1 ENST00000703767.1 ENST00000703760.1 ENST00000703768.1 A0A994J6Z8 A0A994J425 A0A994J4H3 ENST00000703755.1 ENST00000703753.1 A0A994J4G8 ENST00000506284.5 ENST00000264426.14 [P42262-1] ENST00000703754.1 ENST00000505888.1 ENST00000509417.5 H0Y972 A0A994J3V5 ENST00000703752.1 F8W7L6 A0A994J422 ENST00000393815.6 [P42262-4] A0A994J6Z1 A0A994J413 A0A994J418 A0A994J6Y8 ENST00000703764.1 D6RDX5 D6RFM6 D6RBV7 ENST00000703761.1 ENST00000703766.1 A0A994J4F1 A0A994J6J8 ENST00000512774.5 ENST00000703718.1 ENST00000703751.1 A0A994J404

GRIA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review