I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| regulatory T cell | 5 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| regulatory T cell | 5 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of IL21R at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 356.44 | 578 / 578 | 81% | 3.43 | 930 / 1155 |
| kidney | 98% | 105.04 | 87 / 89 | 55% | 1.95 | 496 / 901 |
| thymus | 88% | 86.10 | 574 / 653 | 59% | 3.13 | 354 / 605 |
| stomach | 50% | 23.83 | 180 / 359 | 62% | 2.31 | 178 / 286 |
| skin | 52% | 27.22 | 945 / 1809 | 60% | 3.49 | 281 / 472 |
| intestine | 56% | 83.51 | 545 / 966 | 54% | 2.11 | 283 / 527 |
| breast | 33% | 11.49 | 150 / 459 | 73% | 2.85 | 812 / 1118 |
| brain | 65% | 41.22 | 1720 / 2642 | 36% | 1.60 | 257 / 705 |
| prostate | 86% | 52.75 | 211 / 245 | 14% | 0.30 | 70 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 86.25 | 29 / 29 |
| spleen | 100% | 574.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| bladder | 52% | 26.00 | 11 / 21 | 47% | 1.94 | 238 / 504 |
| peripheral blood | 99% | 1856.42 | 923 / 929 | 0% | 0 | 0 / 0 |
| uterus | 41% | 12.95 | 70 / 170 | 55% | 2.08 | 253 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 7.29 | 39 / 45 |
| esophagus | 36% | 19.49 | 522 / 1445 | 48% | 1.24 | 88 / 183 |
| pancreas | 10% | 3.46 | 33 / 328 | 62% | 2.17 | 110 / 178 |
| liver | 46% | 19.15 | 103 / 226 | 17% | 0.51 | 68 / 406 |
| adrenal gland | 43% | 16.78 | 110 / 258 | 10% | 0.38 | 24 / 230 |
| heart | 51% | 35.27 | 437 / 861 | 0% | 0 | 0 / 0 |
| ovary | 11% | 3.78 | 20 / 180 | 38% | 1.04 | 163 / 430 |
| adipose | 44% | 19.04 | 531 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 42% | 29.59 | 566 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.28 | 9 / 80 |
| muscle | 10% | 13.04 | 81 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0030101 | Biological process | natural killer cell activation |
| GO_0016064 | Biological process | immunoglobulin mediated immune response |
| GO_0038114 | Biological process | interleukin-21-mediated signaling pathway |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0001532 | Molecular function | interleukin-21 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| Gene name | IL21R |
| Protein name | Interleukin 21 receptor Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360) |
| Synonyms | UNQ3121/PRO10273 NILR |
| Description | FUNCTION: This is a receptor for interleukin-21. |
| Accessions | A0A8V8TL34 ENST00000564089.5 ENST00000337929.8 Q9HBE5 ENST00000697146.1 ENST00000395754.4 |
