LRP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0035904Biological processaorta development
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0008283Biological processcell population proliferation
GO_0006897Biological processendocytosis
GO_0044321Biological processresponse to leptin
GO_0006898Biological processreceptor-mediated endocytosis
GO_0150104Biological processtransport across blood-brain barrier
GO_0030900Biological processforebrain development
GO_0015889Biological processcobalamin transport
GO_0050769Biological processpositive regulation of neurogenesis
GO_0001822Biological processkidney development
GO_0003281Biological processventricular septum development
GO_0003223Biological processventricular compact myocardium morphogenesis
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0071363Biological processcellular response to growth factor stimulus
GO_0030001Biological processmetal ion transport
GO_0097242Biological processamyloid-beta clearance
GO_1904447Biological processfolate import across plasma membrane
GO_0042359Biological processvitamin D metabolic process
GO_0001523Biological processretinoid metabolic process
GO_0034311Biological processdiol metabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0060068Biological processvagina development
GO_0140058Biological processneuron projection arborization
GO_0001843Biological processneural tube closure
GO_0061156Biological processpulmonary artery morphogenesis
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0060982Biological processcoronary artery morphogenesis
GO_0008584Biological processmale gonad development
GO_0045056Biological processtranscytosis
GO_0015031Biological processprotein transport
GO_0003139Biological processsecondary heart field specification
GO_0006629Biological processlipid metabolic process
GO_1905167Biological processpositive regulation of lysosomal protein catabolic process
GO_0070447Biological processpositive regulation of oligodendrocyte progenitor proliferation
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0031904Cellular componentendosome lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005905Cellular componentclathrin-coated pit
GO_0030424Cellular componentaxon
GO_0005765Cellular componentlysosomal membrane
GO_0042562Molecular functionhormone binding
GO_0038024Molecular functioncargo receptor activity
GO_0031994Molecular functioninsulin-like growth factor I binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005041Molecular functionlow-density lipoprotein particle receptor activity
GO_0140318Molecular functionprotein transporter activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameLRP2
Protein nameLDL receptor related protein 2
Uncharacterized protein LRP2
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Alternative protein LRP2
Low density lipoprotein receptor-related protein II
Synonyms
DescriptionFUNCTION: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals . Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney . Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). .

AccessionsE9PC35
L8E983
A0A3B3IT64
Q9NP34
ENST00000649046.1
A0A3B3IRR0
P98164
ENST00000650252.1
ENST00000443831.1
Q53TL0
ENST00000649153.1
Q4ZG84