RTN4RL2 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	28% ± 13%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RTN4RL2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1026.64	226 / 226	96%	21.80	389 / 406
thymus	100%	1612.55	653 / 653	93%	24.23	563 / 605
breast	97%	181.04	445 / 459	83%	5.02	923 / 1118
brain	78%	466.51	2063 / 2642	91%	11.92	641 / 705
skin	98%	182.92	1780 / 1809	66%	4.60	313 / 472
kidney	100%	122.69	89 / 89	59%	4.33	533 / 901
prostate	78%	75.00	192 / 245	80%	3.69	401 / 502
lung	94%	120.15	542 / 578	64%	8.67	734 / 1155
esophagus	74%	68.08	1065 / 1445	72%	5.10	132 / 183
pancreas	70%	57.57	228 / 328	47%	2.05	84 / 178
uterus	82%	81.06	140 / 170	29%	2.03	134 / 459
stomach	59%	45.41	211 / 359	52%	5.56	150 / 286
ovary	43%	37.46	78 / 180	55%	3.58	238 / 430
adipose	97%	173.64	1166 / 1204	0%	0	0 / 0
heart	86%	82.70	743 / 861	0%	0	0 / 0
bladder	57%	47.38	12 / 21	23%	1.97	114 / 504
intestine	47%	37.39	453 / 966	31%	1.68	166 / 527
eye	0%	0	0 / 0	64%	2.48	51 / 80
blood vessel	50%	49.09	672 / 1335	0%	0	0 / 0
spleen	47%	31.52	113 / 241	0%	0	0 / 0
adrenal gland	19%	13.33	49 / 258	18%	0.82	42 / 230
muscle	29%	18.52	235 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	20%	0.88	9 / 45
peripheral blood	5%	3.28	44 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0031103	Biological process	axon regeneration
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0043204	Cellular component	perikaryon
GO_0005615	Cellular component	extracellular space
GO_0009986	Cellular component	cell surface
GO_0030424	Cellular component	axon
GO_0009897	Cellular component	external side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0031012	Cellular component	extracellular matrix
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0038023	Molecular function	signaling receptor activity

Gene name	RTN4RL2
Protein name	Reticulon-4 receptor-like 2 (Nogo receptor-like 3) (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) Reticulon 4 receptor-like 2 Reticulon 4 receptor like 2 (Reticulon 4 receptor-like 2, isoform CRA_a)
Synonyms	NGRL3 hCG_39768 NGRH1
Description	FUNCTION: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton . .
Accessions	G3V1D7 Q86UN3 ENST00000335099.8 [Q86UN3-1] B7ZLI0 ENST00000533205.5 ENST00000395120.2 [Q86UN3-2]

RTN4RL2 report