TNFRSF14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046642Biological processnegative regulation of alpha-beta T cell proliferation
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0031295Biological processT cell costimulation
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0046718Biological processsymbiont entry into host cell
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_1905675Biological processnegative regulation of adaptive immune memory response
GO_2000406Biological processpositive regulation of T cell migration
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0019955Molecular functioncytokine binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0001618Molecular functionvirus receptor activity
GO_0005031Molecular functiontumor necrosis factor receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFRSF14
Protein nameTumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
TNF receptor superfamily member 14 (Tumor necrosis factor receptor superfamily member 14)
SynonymsHVEA
HVEM
UNQ329/PRO509
DescriptionFUNCTION: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network . Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation . Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions . Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response . In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response . May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. .; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. .

AccessionsENST00000629209.1
Q92956
ENST00000409119.5
F6UPZ7
ENST00000628337.2
ENST00000629542.2
A0A0D9SF52
ENST00000482602.5
F6Q0M4
ENST00000631202.2
ENST00000434817.5
ENST00000625695.2
ENST00000435221.6
ENST00000355716.5 [Q92956-1]
ENST00000451778.5
ENST00000629075.2
B9A034
ENST00000426449.5
ENST00000621877.3 [Q92956-1]