LRRC32 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRRC32 at tissue level.

III. Associated gene sets

GO_0035592Biological processestablishment of protein localization to extracellular region
GO_0010628Biological processpositive regulation of gene expression
GO_0062009Biological processsecondary palate development
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0001818Biological processnegative regulation of cytokine production
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0031012Cellular componentextracellular matrix
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0141069Molecular functionreceptor ligand inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRC32
Protein nameLeucine rich repeat containing 32
Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
SynonymsD11S833E
DescriptionFUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta . Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta . Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) . Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). .

AccessionsENST00000404995.5
ENST00000407242.6
ENST00000260061.9
ENST00000421973.1
Q14392
C9JYU3