TMEM123 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	35% ± 12%	Explore
macrophage	36 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	33 studies	43% ± 17%	Explore
B cell	31 studies	29% ± 12%	Explore
T cell	30 studies	33% ± 15%	Explore
conventional dendritic cell	27 studies	36% ± 13%	Explore
CD8-positive, alpha-beta T cell	26 studies	33% ± 16%	Explore
regulatory T cell	25 studies	40% ± 14%	Explore
classical monocyte	24 studies	34% ± 13%	Explore
fibroblast	23 studies	25% ± 8%	Explore
basal cell	23 studies	39% ± 17%	Explore
natural killer cell	22 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	21 studies	43% ± 16%	Explore
non-classical monocyte	21 studies	33% ± 11%	Explore
epithelial cell	20 studies	36% ± 19%	Explore
monocyte	19 studies	31% ± 9%	Explore
ciliated cell	19 studies	53% ± 17%	Explore
naive B cell	19 studies	38% ± 11%	Explore
dendritic cell	18 studies	36% ± 17%	Explore
memory B cell	18 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	49% ± 16%	Explore
smooth muscle cell	17 studies	27% ± 11%	Explore
pericyte	17 studies	24% ± 7%	Explore
gamma-delta T cell	16 studies	34% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	49% ± 15%	Explore
mucosal invariant T cell	14 studies	34% ± 12%	Explore
mature NK T cell	14 studies	25% ± 8%	Explore
capillary endothelial cell	14 studies	34% ± 14%	Explore
oligodendrocyte	13 studies	29% ± 12%	Explore
myeloid cell	13 studies	35% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	35% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	45% ± 16%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 8%	Explore
myofibroblast cell	12 studies	20% ± 5%	Explore
vein endothelial cell	12 studies	30% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 11%	Explore
secretory cell	11 studies	35% ± 11%	Explore
endothelial cell of artery	11 studies	28% ± 5%	Explore
endothelial cell of vascular tree	11 studies	27% ± 7%	Explore
type I pneumocyte	10 studies	27% ± 10%	Explore
club cell	10 studies	30% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 12%	Explore
connective tissue cell	10 studies	27% ± 8%	Explore
goblet cell	10 studies	30% ± 14%	Explore
plasma cell	9 studies	23% ± 8%	Explore
leukocyte	9 studies	31% ± 7%	Explore
abnormal cell	9 studies	31% ± 9%	Explore
innate lymphoid cell	8 studies	38% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 13%	Explore
astrocyte	8 studies	24% ± 9%	Explore
T follicular helper cell	8 studies	49% ± 11%	Explore
alveolar macrophage	7 studies	21% ± 6%	Explore
plasmablast	7 studies	38% ± 15%	Explore
respiratory goblet cell	7 studies	29% ± 13%	Explore
platelet	7 studies	20% ± 2%	Explore
progenitor cell	7 studies	30% ± 13%	Explore
hematopoietic stem cell	7 studies	41% ± 12%	Explore
precursor B cell	7 studies	47% ± 15%	Explore
hematopoietic precursor cell	6 studies	47% ± 17%	Explore
ionocyte	6 studies	35% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	35% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
mononuclear phagocyte	6 studies	43% ± 15%	Explore
renal alpha-intercalated cell	6 studies	33% ± 8%	Explore
mesothelial cell	6 studies	29% ± 16%	Explore
immature B cell	6 studies	40% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	49% ± 15%	Explore
CD4-positive helper T cell	5 studies	31% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	24% ± 8%	Explore
intestinal crypt stem cell	5 studies	26% ± 3%	Explore
transit amplifying cell	5 studies	26% ± 9%	Explore
lymphocyte	5 studies	30% ± 10%	Explore
pro-B cell	5 studies	50% ± 8%	Explore
hepatocyte	5 studies	48% ± 28%	Explore
mast cell	5 studies	21% ± 7%	Explore
neutrophil	5 studies	21% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	36% ± 11%	Explore
deuterosomal cell	4 studies	25% ± 6%	Explore
duct epithelial cell	4 studies	37% ± 8%	Explore
mucus secreting cell	4 studies	39% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	30% ± 10%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 11%	Explore
T-helper 17 cell	4 studies	41% ± 7%	Explore
microglial cell	4 studies	19% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	40% ± 18%	Explore
glomerular endothelial cell	3 studies	44% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	43% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 3%	Explore
neural crest cell	3 studies	28% ± 2%	Explore
thymocyte	3 studies	29% ± 16%	Explore
serous secreting cell	3 studies	58% ± 19%	Explore
tissue-resident macrophage	3 studies	36% ± 12%	Explore
erythroblast	3 studies	24% ± 4%	Explore
acinar cell	3 studies	54% ± 21%	Explore
germinal center B cell	3 studies	50% ± 11%	Explore
intermediate monocyte	3 studies	48% ± 22%	Explore
endothelial cell of sinusoid	3 studies	31% ± 7%	Explore
pancreatic ductal cell	3 studies	64% ± 20%	Explore
ependymal cell	3 studies	39% ± 10%	Explore
granulocyte	3 studies	31% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	59% ± 14%	Explore
enteroendocrine cell	3 studies	29% ± 13%	Explore
glial cell	3 studies	35% ± 18%	Explore
keratinocyte	3 studies	27% ± 4%	Explore
T-helper 1 cell	3 studies	48% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	54% ± 10%	Explore
double negative thymocyte	3 studies	45% ± 15%	Explore
double-positive, alpha-beta thymocyte	3 studies	60% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 4%	Explore
erythrocyte	3 studies	32% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	38% ± 11%	Explore
lung	18 studies	32% ± 14%	Explore
intestine	9 studies	24% ± 8%	Explore
brain	8 studies	23% ± 10%	Explore
kidney	7 studies	23% ± 5%	Explore
liver	6 studies	29% ± 8%	Explore
lymph node	5 studies	33% ± 9%	Explore
bone marrow	4 studies	33% ± 11%	Explore
uterus	4 studies	35% ± 16%	Explore
breast	4 studies	25% ± 3%	Explore
prostate	4 studies	29% ± 10%	Explore
pancreas	3 studies	35% ± 17%	Explore
thymus	3 studies	45% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6618.41	1445 / 1445	100%	249.15	183 / 183
ovary	100%	7424.91	180 / 180	100%	180.70	429 / 430
lung	100%	9789.51	577 / 578	100%	282.63	1154 / 1155
prostate	100%	7696.89	245 / 245	99%	259.49	499 / 502
intestine	100%	10415.14	966 / 966	99%	259.44	523 / 527
thymus	100%	14129.85	653 / 653	99%	255.72	599 / 605
breast	100%	7729.64	459 / 459	99%	253.03	1106 / 1118
uterus	100%	17633.52	170 / 170	99%	293.28	454 / 459
bladder	100%	8528.29	21 / 21	99%	246.23	498 / 504
stomach	100%	6614.31	359 / 359	99%	247.10	282 / 286
liver	100%	14669.96	226 / 226	98%	209.22	398 / 406
pancreas	98%	4562.06	323 / 328	98%	194.60	174 / 178
kidney	100%	5821.00	89 / 89	95%	203.65	859 / 901
brain	85%	3561.50	2233 / 2642	99%	123.23	698 / 705
skin	100%	11624.33	1808 / 1809	81%	104.72	384 / 472
adrenal gland	100%	6728.69	258 / 258	59%	49.09	136 / 230
adipose	100%	7203.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	167.80	29 / 29
spleen	100%	6210.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	198.82	45 / 45
ureter	0%	0	0 / 0	100%	60.13	1 / 1
blood vessel	100%	6108.32	1330 / 1335	0%	0	0 / 0
heart	94%	3781.20	812 / 861	0%	0	0 / 0
peripheral blood	88%	6324.40	818 / 929	0%	0	0 / 0
muscle	49%	1036.53	392 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	49%	35.65	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	TMEM123
Protein name	Alternative protein TMEM123 Transmembrane protein 123 Porimin (Keratinocytes-associated transmembrane protein 3) (KCT-3) (Pro-oncosis receptor inducing membrane injury) (Transmembrane protein 123)
Synonyms	KCT3 UNQ641/PRO1271 PSEC0111
Description	FUNCTION: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. .
Accessions	E9PJW0 ENST00000398136.7 [Q8N131-1] ENST00000531103.5 ENST00000532161.5 E9PSB1 L8EBC6 E9PKT4 Q8N131 ENST00000528969.5 ENST00000526676.1 ENST00000361236.7 [Q8N131-2]

GO_0009897	Cellular component	external side of plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0005515	Molecular function	protein binding

TMEM123 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review