Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 39 studies | 35% ± 13% | |
| naive B cell | 19 studies | 43% ± 14% | |
| memory B cell | 17 studies | 36% ± 12% | |
| oligodendrocyte | 15 studies | 43% ± 17% | |
| mast cell | 9 studies | 24% ± 10% | |
| precursor B cell | 5 studies | 37% ± 14% | |
| immature B cell | 5 studies | 46% ± 6% | |
| pro-B cell | 3 studies | 27% ± 9% | |
| germinal center B cell | 3 studies | 59% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 28% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 98% | 17576.63 | 177 / 180 | 71% | 11.15 | 307 / 430 |
| lung | 88% | 764.28 | 511 / 578 | 55% | 4.58 | 633 / 1155 |
| thymus | 60% | 911.89 | 394 / 653 | 79% | 17.47 | 480 / 605 |
| brain | 89% | 2251.71 | 2362 / 2642 | 46% | 3.64 | 327 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 181.76 | 29 / 29 |
| spleen | 100% | 22364.98 | 241 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 74% | 655.92 | 190 / 258 | 25% | 4.81 | 58 / 230 |
| peripheral blood | 95% | 7872.36 | 881 / 929 | 0% | 0 | 0 / 0 |
| breast | 20% | 103.34 | 91 / 459 | 71% | 6.02 | 797 / 1118 |
| bladder | 62% | 303.14 | 13 / 21 | 19% | 2.90 | 97 / 504 |
| kidney | 26% | 202.99 | 23 / 89 | 52% | 3.38 | 465 / 901 |
| skin | 1% | 5.52 | 10 / 1809 | 75% | 17.31 | 353 / 472 |
| prostate | 53% | 386.50 | 131 / 245 | 20% | 1.03 | 102 / 502 |
| intestine | 49% | 1901.60 | 470 / 966 | 21% | 3.44 | 110 / 527 |
| esophagus | 40% | 236.81 | 571 / 1445 | 20% | 2.05 | 36 / 183 |
| uterus | 41% | 420.70 | 70 / 170 | 18% | 1.71 | 82 / 459 |
| stomach | 29% | 150.05 | 105 / 359 | 30% | 3.97 | 85 / 286 |
| pancreas | 1% | 4.31 | 3 / 328 | 55% | 8.54 | 98 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 47% | 7.48 | 21 / 45 |
| eye | 0% | 0 | 0 / 0 | 33% | 2.16 | 26 / 80 |
| adipose | 23% | 132.88 | 277 / 1204 | 0% | 0 | 0 / 0 |
| liver | 6% | 26.44 | 13 / 226 | 14% | 2.01 | 58 / 406 |
| blood vessel | 6% | 76.41 | 81 / 1335 | 0% | 0 | 0 / 0 |
| heart | 4% | 18.82 | 31 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050859 | Biological process | negative regulation of B cell receptor signaling pathway |
| GO_0007155 | Biological process | cell adhesion |
| GO_0050776 | Biological process | regulation of immune response |
| GO_0030888 | Biological process | regulation of B cell proliferation |
| GO_0002638 | Biological process | negative regulation of immunoglobulin production |
| GO_0050849 | Biological process | negative regulation of calcium-mediated signaling |
| GO_0042113 | Biological process | B cell activation |
| GO_0030100 | Biological process | regulation of endocytosis |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0032809 | Cellular component | neuronal cell body membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0001791 | Molecular function | IgM binding |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0033691 | Molecular function | sialic acid binding |
| GO_0030246 | Molecular function | carbohydrate binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042609 | Molecular function | CD4 receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CD22 |
| Protein name | CD22 protein B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 molecule B-cell receptor CD22 (Sialic acid-binding Ig-like lectin 2) |
| Synonyms | SIGLEC2 |
| Description | FUNCTION: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| Accessions | ENST00000613136.1 M0R2R8 ENST00000085219.10 [P20273-1] ENST00000600131.5 M0R1M2 Q9UQB1 ENST00000598537.5 ENST00000536635.6 [P20273-3] P20273 M0QZP5 ENST00000599717.5 ENST00000341773.10 [P20273-2] M0R0R6 O95700 Q9UQB2 A0A087WZQ4 ENST00000544992.6 [P20273-4] M0R3H1 ENST00000597916.5 ENST00000600424.5 ENST00000594250.5 [P20273-2] ENST00000599811.5 ENST00000593867.5 M0QY05 ENST00000595780.5 M0QY14 Q0EAF5 O60926 ENST00000419549.6 [P20273-5] M0QYP4 M0R2M0 ENST00000594125.1 M0QZR7 ENST00000601769.5 M0QZ01 ENST00000594349.1 |
