Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| kidney loop of Henle epithelial cell | 6 studies | 27% ± 7% | |
| astrocyte | 4 studies | 41% ± 21% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 80% ± 3% | |
| pancreatic ductal cell | 3 studies | 53% ± 14% | |
| hepatocyte | 3 studies | 48% ± 30% |
Insufficient scRNA-seq data for expression of SERPINA5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 13184.18 | 226 / 226 | 96% | 304.42 | 391 / 406 |
| pancreas | 100% | 7028.39 | 328 / 328 | 76% | 67.25 | 136 / 178 |
| adrenal gland | 100% | 49753.75 | 258 / 258 | 59% | 331.73 | 135 / 230 |
| ovary | 96% | 3030.67 | 172 / 180 | 53% | 62.15 | 229 / 430 |
| breast | 77% | 1128.66 | 354 / 459 | 64% | 66.14 | 713 / 1118 |
| kidney | 100% | 8465.73 | 89 / 89 | 17% | 17.20 | 153 / 901 |
| spleen | 100% | 11462.99 | 241 / 241 | 0% | 0 | 0 / 0 |
| stomach | 78% | 845.65 | 281 / 359 | 9% | 3.99 | 25 / 286 |
| muscle | 67% | 2472.17 | 541 / 803 | 0% | 0 | 0 / 0 |
| prostate | 60% | 643.99 | 146 / 245 | 1% | 0.25 | 3 / 502 |
| skin | 26% | 189.78 | 479 / 1809 | 32% | 27.71 | 151 / 472 |
| intestine | 48% | 357.45 | 463 / 966 | 8% | 4.38 | 42 / 527 |
| heart | 54% | 777.83 | 466 / 861 | 0% | 0 | 0 / 0 |
| thymus | 48% | 370.76 | 312 / 653 | 1% | 0.17 | 4 / 605 |
| esophagus | 33% | 245.48 | 481 / 1445 | 7% | 3.56 | 13 / 183 |
| adipose | 33% | 293.39 | 400 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 25% | 338.76 | 43 / 170 | 8% | 4.46 | 35 / 459 |
| blood vessel | 27% | 275.71 | 366 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 14% | 74.62 | 3 / 21 | 2% | 0.69 | 9 / 504 |
| brain | 4% | 28.70 | 113 / 2642 | 9% | 3.52 | 62 / 705 |
| lung | 5% | 32.19 | 30 / 578 | 6% | 1.59 | 66 / 1155 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.47 | 1 / 29 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.32 | 1 / 80 |
| peripheral blood | 0% | 2.66 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0010951 | Biological process | negative regulation of endopeptidase activity |
| GO_0006869 | Biological process | lipid transport |
| GO_0007342 | Biological process | fusion of sperm to egg plasma membrane involved in single fertilization |
| GO_0051346 | Biological process | negative regulation of hydrolase activity |
| GO_0005615 | Cellular component | extracellular space |
| GO_0031091 | Cellular component | platelet alpha granule |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0097181 | Cellular component | protein C inhibitor-coagulation factor V complex |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0036030 | Cellular component | protein C inhibitor-plasma kallikrein complex |
| GO_0002080 | Cellular component | acrosomal membrane |
| GO_0031094 | Cellular component | platelet dense tubular network |
| GO_0036025 | Cellular component | protein C inhibitor-TMPRSS11E complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0097183 | Cellular component | protein C inhibitor-coagulation factor XI complex |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0097182 | Cellular component | protein C inhibitor-coagulation factor Xa complex |
| GO_0036028 | Cellular component | protein C inhibitor-thrombin complex |
| GO_0036029 | Cellular component | protein C inhibitor-KLK3 complex |
| GO_0036026 | Cellular component | protein C inhibitor-PLAT complex |
| GO_0036024 | Cellular component | protein C inhibitor-TMPRSS7 complex |
| GO_0036027 | Cellular component | protein C inhibitor-PLAU complex |
| GO_0008201 | Molecular function | heparin binding |
| GO_0004867 | Molecular function | serine-type endopeptidase inhibitor activity |
| GO_0002020 | Molecular function | protease binding |
| GO_0031210 | Molecular function | phosphatidylcholine binding |
| GO_0001972 | Molecular function | retinoic acid binding |
| GO_0005539 | Molecular function | glycosaminoglycan binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0032190 | Molecular function | acrosin binding |
| Gene name | SERPINA5 |
| Protein name | Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5) Serpin family A member 5 |
| Synonyms | PROCI PCI PLANH3 |
| Description | FUNCTION: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid. . |
| Accessions | ENST00000554220.5 G3V3Y3 ENST00000554276.1 ENST00000556775.5 ENST00000554633.5 ENST00000557598.1 ENST00000556064.1 ENST00000555681.1 P05154 G3V4B4 ENST00000554866.5 G3V3F5 ENST00000553511.1 G3V264 ENST00000329597.12 G3V482 G3V265 ENST00000553780.5 G3V2M1 |
