AQP4 | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	3555.61	2517 / 2642	99%	779.23	699 / 705
lung	93%	1606.27	535 / 578	48%	28.84	560 / 1155
thymus	42%	184.76	272 / 653	37%	9.33	221 / 605
muscle	42%	281.25	337 / 803	0%	0	0 / 0
stomach	31%	140.69	110 / 359	0%	0	0 / 286
heart	8%	28.70	71 / 861	0%	0	0 / 0
bladder	0%	0	0 / 21	4%	2.53	22 / 504
lymph node	0%	0	0 / 0	3%	0.33	1 / 29
adrenal gland	0%	0	0 / 258	3%	0.44	6 / 230
eye	0%	0	0 / 0	3%	0.65	2 / 80
kidney	0%	0	0 / 89	2%	0.60	22 / 901
breast	0%	0	0 / 459	2%	0.50	18 / 1118
ovary	1%	4.94	2 / 180	0%	0.09	2 / 430
uterus	0%	0	0 / 170	2%	0.57	7 / 459
pancreas	0%	0	0 / 328	1%	0.12	2 / 178
esophagus	0%	1.50	6 / 1445	1%	0.17	1 / 183
skin	0%	0	0 / 1809	1%	0.15	3 / 472
liver	0%	0	0 / 226	0%	0.11	2 / 406
intestine	0%	0	0 / 966	0%	0.03	1 / 527
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006833	Biological process	water transport
GO_0090660	Biological process	cerebrospinal fluid circulation
GO_0003091	Biological process	renal water homeostasis
GO_0050891	Biological process	multicellular organismal-level water homeostasis
GO_0009992	Biological process	intracellular water homeostasis
GO_0071346	Biological process	cellular response to type II interferon
GO_0055085	Biological process	transmembrane transport
GO_0051289	Biological process	protein homotetramerization
GO_0010008	Cellular component	endosome membrane
GO_0042383	Cellular component	sarcolemma
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0097450	Cellular component	astrocyte end-foot
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0015250	Molecular function	water channel activity
GO_0005515	Molecular function	protein binding

Gene name	AQP4
Protein name	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aquaporin-4 Aquaporin 4 Alternative protein AQP4 Aquaporin type4 transcript variant c
Synonyms	hCG_37174
Description	FUNCTION: Forms a water-specific channel . Plays an important role in brain water homeostasis . It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). .
Accessions	ENST00000578776.1 Q6L7A0 ENST00000440832.7 [P55087-2] J3KRM4 V9PBN7 ENST00000672981.2 ENST00000672188.1 [P55087-1] F1DSG4 ENST00000675739.1 L0R6C7 ENST00000383170.3 Q9H3V7 H0Y3H5 A0A5F9ZHR4 P55087 ENST00000581374.5 [P55087-2] ENST00000383168.9 [P55087-1]

AQP4 report