CD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0035723Biological processinterleukin-15-mediated signaling pathway
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0019722Biological processcalcium-mediated signaling
GO_0051924Biological processregulation of calcium ion transport
GO_0030225Biological processmacrophage differentiation
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0007165Biological processsignal transduction
GO_0007167Biological processenzyme-linked receptor protein signaling pathway
GO_0046598Biological processpositive regulation of viral entry into host cell
GO_0035397Biological processhelper T cell enhancement of adaptive immune response
GO_0007155Biological processcell adhesion
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0045657Biological processpositive regulation of monocyte differentiation
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0030217Biological processT cell differentiation
GO_0033674Biological processpositive regulation of kinase activity
GO_0046718Biological processsymbiont entry into host cell
GO_0045058Biological processT cell selection
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0050863Biological processregulation of T cell activation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0042110Biological processT cell activation
GO_0032507Biological processmaintenance of protein location in cell
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0042101Cellular componentT cell receptor complex
GO_0019899Molecular functionenzyme binding
GO_0015026Molecular functioncoreceptor activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0038023Molecular functionsignaling receptor activity
GO_0008289Molecular functionlipid binding
GO_0042289Molecular functionMHC class II protein binding
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0042011Molecular functioninterleukin-16 binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0042012Molecular functioninterleukin-16 receptor activity
GO_0001618Molecular functionvirus receptor activity
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0008270Molecular functionzinc ion binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD4
Protein nameT-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Surface glycoprotein variant
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3)
CD4 molecule
CD4 protein (CD4 receptor)
Synonyms
DescriptionFUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. .; FUNCTION: (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 . .

AccessionsQ13969
ENST00000541982.5
Q6LCP8
A0A4Y5UGE4
F5H480
ENST00000539492.1
F5GYA9
ENST00000011653.9
P01730