Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 28 studies | 59% ± 22% | |
| capillary endothelial cell | 6 studies | 33% ± 7% | |
| endothelial cell | 3 studies | 19% ± 2% | |
| glomerular endothelial cell | 3 studies | 39% ± 12% | |
| granulocyte | 3 studies | 62% ± 10% |
Insufficient scRNA-seq data for expression of IL1RL1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 96% | 17631.78 | 85 / 89 | 57% | 5.40 | 516 / 901 |
| lung | 100% | 28764.51 | 577 / 578 | 48% | 3.41 | 556 / 1155 |
| adrenal gland | 97% | 4895.01 | 251 / 258 | 22% | 0.78 | 51 / 230 |
| stomach | 87% | 3139.17 | 311 / 359 | 30% | 0.94 | 87 / 286 |
| thymus | 50% | 739.21 | 328 / 653 | 58% | 24.58 | 352 / 605 |
| esophagus | 53% | 488.43 | 772 / 1445 | 45% | 1.79 | 83 / 183 |
| breast | 76% | 2509.92 | 348 / 459 | 22% | 0.70 | 246 / 1118 |
| pancreas | 39% | 331.96 | 129 / 328 | 57% | 2.28 | 102 / 178 |
| adipose | 92% | 2769.40 | 1103 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 67% | 1067.19 | 14 / 21 | 20% | 1.27 | 101 / 504 |
| intestine | 60% | 775.04 | 582 / 966 | 23% | 0.69 | 122 / 527 |
| prostate | 54% | 861.04 | 133 / 245 | 16% | 0.37 | 82 / 502 |
| heart | 71% | 2248.18 | 608 / 861 | 0% | 0 | 0 / 0 |
| liver | 54% | 1635.76 | 122 / 226 | 11% | 0.31 | 46 / 406 |
| skin | 58% | 630.32 | 1044 / 1809 | 3% | 0.09 | 14 / 472 |
| uterus | 39% | 239.45 | 66 / 170 | 14% | 0.52 | 65 / 459 |
| brain | 35% | 760.85 | 935 / 2642 | 17% | 0.63 | 120 / 705 |
| blood vessel | 41% | 485.82 | 553 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 40% | 313.33 | 375 / 929 | 0% | 0 | 0 / 0 |
| muscle | 21% | 195.80 | 165 / 803 | 0% | 0 | 0 / 0 |
| spleen | 20% | 139.05 | 47 / 241 | 0% | 0 | 0 / 0 |
| ovary | 11% | 102.43 | 19 / 180 | 3% | 0.09 | 14 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.58 | 6 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002826 | Biological process | negative regulation of T-helper 1 type immune response |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0006954 | Biological process | inflammatory response |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0038172 | Biological process | interleukin-33-mediated signaling pathway |
| GO_0043032 | Biological process | positive regulation of macrophage activation |
| GO_0006955 | Biological process | immune response |
| GO_0032754 | Biological process | positive regulation of interleukin-5 production |
| GO_0032689 | Biological process | negative regulation of type II interferon production |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0002114 | Molecular function | interleukin-33 receptor activity |
| GO_0003953 | Molecular function | NAD+ nucleosidase activity |
| GO_0002113 | Molecular function | interleukin-33 binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0004908 | Molecular function | interleukin-1 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0061809 | Molecular function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| Gene name | IL1RL1 |
| Protein name | Interleukin 1 receptor-like 1 isoform 2 Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2) Interleukin 1 receptor like 1 Interleukin 1 receptor-like 1 isoform 1 |
| Synonyms | ST2 DER4 T1 |
| Description | FUNCTION: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP . Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). .; FUNCTION: [Isoform B]: Inhibits IL-33 signaling. . |
| Accessions | Q01638 A8VPW9 ENST00000427077.1 [Q01638-3] A8VPX0 ENST00000409584.5 ENST00000404917.6 [Q01638-4] ENST00000233954.6 [Q01638-1] ENST00000447231.5 ENST00000311734.6 [Q01638-2] C9JSY6 E9PC41 |
