Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 23815.45 | 653 / 653 | 100% | 83.13 | 604 / 605 |
| breast | 100% | 40157.61 | 459 / 459 | 98% | 78.88 | 1101 / 1118 |
| lung | 100% | 58276.00 | 578 / 578 | 97% | 66.67 | 1126 / 1155 |
| bladder | 100% | 14260.33 | 21 / 21 | 89% | 39.56 | 448 / 504 |
| kidney | 97% | 12913.61 | 86 / 89 | 92% | 197.73 | 829 / 901 |
| intestine | 96% | 11715.29 | 926 / 966 | 90% | 42.14 | 473 / 527 |
| uterus | 99% | 16729.16 | 168 / 170 | 81% | 30.55 | 370 / 459 |
| esophagus | 87% | 12138.17 | 1251 / 1445 | 92% | 49.06 | 169 / 183 |
| stomach | 85% | 7636.21 | 306 / 359 | 92% | 54.68 | 262 / 286 |
| prostate | 84% | 7796.12 | 205 / 245 | 87% | 31.25 | 435 / 502 |
| adrenal gland | 63% | 3783.56 | 163 / 258 | 92% | 66.10 | 212 / 230 |
| skin | 64% | 7031.25 | 1164 / 1809 | 88% | 42.05 | 415 / 472 |
| pancreas | 30% | 1698.47 | 98 / 328 | 99% | 82.44 | 177 / 178 |
| brain | 25% | 1723.82 | 651 / 2642 | 89% | 32.38 | 629 / 705 |
| adipose | 100% | 49687.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 61.37 | 29 / 29 |
| spleen | 100% | 15691.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 95% | 11404.37 | 816 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 40.40 | 42 / 45 |
| liver | 2% | 116.15 | 4 / 226 | 88% | 31.86 | 356 / 406 |
| ovary | 23% | 2142.62 | 41 / 180 | 65% | 16.75 | 280 / 430 |
| blood vessel | 87% | 12490.41 | 1165 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 79% | 6053.22 | 632 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 78% | 15127.37 | 726 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 25% | 5.31 | 20 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0098742 | Biological process | cell-cell adhesion via plasma-membrane adhesion molecules |
| GO_0007165 | Biological process | signal transduction |
| GO_0035696 | Biological process | monocyte extravasation |
| GO_0072011 | Biological process | glomerular endothelium development |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0050904 | Biological process | diapedesis |
| GO_0006955 | Biological process | immune response |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO_0072672 | Biological process | neutrophil extravasation |
| GO_0008037 | Biological process | cell recognition |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_0035633 | Biological process | maintenance of blood-brain barrier |
| GO_0006909 | Biological process | phagocytosis |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0150107 | Biological process | positive regulation of protein localization to cell-cell junction |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0031092 | Cellular component | platelet alpha granule membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PECAM1 |
| Protein name | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) Platelet and endothelial cell adhesion molecule 1 |
| Synonyms | |
| Description | FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions . Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes . Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions . Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils . Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal . Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes . Modulates bradykinin receptor BDKRB2 activation . Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells . Induces susceptibility to atherosclerosis (By similarity). .; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. . |
| Accessions | ENST00000564866.5 A0A075B737 ENST00000563523.5 ENST00000563924.6 [P16284-1] P16284 A0A075B727 ENST00000569967.1 A0A075B728 |
