MR1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MR1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MR1 at tissue level.

III. Associated gene sets

GO_0002474Biological processantigen processing and presentation of peptide antigen via MHC class I
GO_0002854Biological processpositive regulation of T cell mediated cytotoxicity directed against tumor cell target
GO_0045087Biological processinnate immune response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0033077Biological processT cell differentiation in thymus
GO_0006955Biological processimmune response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0019884Biological processantigen processing and presentation of exogenous antigen
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0042612Cellular componentMHC class I protein complex
GO_0042608Molecular functionT cell receptor binding
GO_0032393Molecular functionMHC class I receptor activity
GO_0030881Molecular functionbeta-2-microglobulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMR1
Protein nameMajor histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
Major histocompatibility complex, class I-related
Major histocompatibility complex class I-related gene protein
Synonyms
DescriptionFUNCTION: Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells . In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers . Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively . May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin . Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells . During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome . May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types . .

AccessionsENST00000684662.1
Q95460
ENST00000617803.5
ENST00000367580.6 [Q95460-1]
A0A8C8PVM5
A0A804HJC9
ENST00000367579.7 [Q95460-2]
ENST00000434571.7 [Q95460-5]
A0A804HIG0
ENST00000614012.5 [Q95460-1]
ENST00000683652.1
ENST00000282990.10 [Q95460-3]