Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD16-positive, CD56-dim natural killer cell, human | 8 studies | 18% ± 2% | |
| natural killer cell | 5 studies | 20% ± 3% | |
| regulatory T cell | 4 studies | 18% ± 2% | |
| CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
| mucosal invariant T cell | 3 studies | 17% ± 2% |
Insufficient scRNA-seq data for expression of IL12RB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 446.22 | 577 / 578 | 91% | 4.53 | 1056 / 1155 |
| intestine | 86% | 269.93 | 833 / 966 | 86% | 3.97 | 453 / 527 |
| stomach | 80% | 88.96 | 287 / 359 | 88% | 4.16 | 252 / 286 |
| kidney | 80% | 100.97 | 71 / 89 | 83% | 4.01 | 745 / 901 |
| breast | 80% | 75.26 | 366 / 459 | 80% | 3.10 | 893 / 1118 |
| bladder | 76% | 102.00 | 16 / 21 | 70% | 3.71 | 352 / 504 |
| brain | 64% | 59.62 | 1678 / 2642 | 80% | 2.39 | 564 / 705 |
| esophagus | 58% | 53.80 | 839 / 1445 | 81% | 3.04 | 148 / 183 |
| prostate | 87% | 101.39 | 212 / 245 | 52% | 1.08 | 261 / 502 |
| thymus | 72% | 93.10 | 470 / 653 | 65% | 2.63 | 391 / 605 |
| uterus | 59% | 42.63 | 101 / 170 | 73% | 3.30 | 334 / 459 |
| liver | 77% | 68.79 | 174 / 226 | 53% | 1.66 | 214 / 406 |
| adrenal gland | 92% | 101.60 | 238 / 258 | 26% | 0.54 | 59 / 230 |
| pancreas | 24% | 16.04 | 79 / 328 | 88% | 3.94 | 157 / 178 |
| ovary | 37% | 24.57 | 66 / 180 | 67% | 1.86 | 290 / 430 |
| skin | 20% | 12.23 | 358 / 1809 | 82% | 7.40 | 386 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 35.17 | 29 / 29 |
| spleen | 100% | 1910.38 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 1563.09 | 928 / 929 | 0% | 0 | 0 / 0 |
| adipose | 93% | 136.07 | 1118 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 6.95 | 41 / 45 |
| blood vessel | 61% | 74.21 | 812 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 39% | 2.09 | 31 / 80 |
| heart | 34% | 23.46 | 292 / 861 | 0% | 0 | 0 / 0 |
| muscle | 1% | 0.65 | 11 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
| GO_0043382 | Biological process | positive regulation of memory T cell differentiation |
| GO_2000318 | Biological process | positive regulation of T-helper 17 type immune response |
| GO_0007165 | Biological process | signal transduction |
| GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
| GO_0038155 | Biological process | interleukin-23-mediated signaling pathway |
| GO_0035722 | Biological process | interleukin-12-mediated signaling pathway |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0002827 | Biological process | positive regulation of T-helper 1 type immune response |
| GO_2000330 | Biological process | positive regulation of T-helper 17 cell lineage commitment |
| GO_0002230 | Biological process | positive regulation of defense response to virus by host |
| GO_0071346 | Biological process | cellular response to type II interferon |
| GO_0072536 | Cellular component | interleukin-23 receptor complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042022 | Cellular component | interleukin-12 receptor complex |
| GO_0042020 | Molecular function | interleukin-23 receptor activity |
| GO_0019955 | Molecular function | cytokine binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0016517 | Molecular function | interleukin-12 receptor activity |
| GO_0005143 | Molecular function | interleukin-12 receptor binding |
| GO_0042019 | Molecular function | interleukin-23 binding |
| Gene name | IL12RB1 |
| Protein name | Interleukin 12 receptor subunit beta 1 Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212) |
| Synonyms | IL12R IL12RB |
| Description | FUNCTION: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. . |
| Accessions | X6RGM1 ENST00000430026.7 M0R382 ENST00000600835.6 [P42701-1] P42701 ENST00000598019.6 ENST00000594176.1 ENST00000593993.7 [P42701-1] ENST00000322153.11 [P42701-3] M0QX06 |
