CLEC6A | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLEC6A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	74%	13.29	426 / 578	20%	0.44	228 / 1155
peripheral blood	84%	29.43	781 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	55%	2.43	16 / 29
spleen	46%	3.13	112 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	22%	0.40	10 / 45
kidney	12%	0.52	11 / 89	3%	0.05	27 / 901
bladder	10%	0.33	2 / 21	6%	0.11	29 / 504
stomach	3%	0.13	11 / 359	10%	0.19	28 / 286
adipose	13%	0.64	152 / 1204	0%	0	0 / 0
breast	5%	0.22	23 / 459	7%	0.18	81 / 1118
intestine	6%	0.38	55 / 966	6%	0.11	33 / 527
uterus	7%	0.28	12 / 170	3%	0.05	15 / 459
skin	2%	0.07	28 / 1809	8%	0.15	37 / 472
pancreas	6%	0.27	19 / 328	3%	0.06	5 / 178
blood vessel	7%	0.34	91 / 1335	0%	0	0 / 0
esophagus	3%	0.14	42 / 1445	4%	0.06	7 / 183
thymus	5%	0.24	33 / 653	1%	0.02	9 / 605
ovary	2%	0.06	3 / 180	4%	0.06	16 / 430
prostate	4%	0.20	11 / 245	0%	0.01	1 / 502
adrenal gland	4%	0.18	11 / 258	0%	0	0 / 230
brain	2%	0.11	61 / 2642	0%	0.01	2 / 705
heart	2%	0.08	15 / 861	0%	0	0 / 0
liver	1%	0.03	2 / 226	1%	0.01	3 / 406
muscle	1%	0.04	6 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050832	Biological process	defense response to fungus
GO_0061760	Biological process	antifungal innate immune response
GO_0045087	Biological process	innate immune response
GO_2000318	Biological process	positive regulation of T-helper 17 type immune response
GO_1902533	Biological process	positive regulation of intracellular signal transduction
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0002250	Biological process	adaptive immune response
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0001878	Biological process	response to yeast
GO_0001819	Biological process	positive regulation of cytokine production
GO_0001879	Biological process	detection of yeast
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0038187	Molecular function	pattern recognition receptor activity
GO_0005537	Molecular function	D-mannose binding
GO_0030246	Molecular function	carbohydrate binding
GO_0043274	Molecular function	phospholipase binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

Gene name	CLEC6A
Protein name	C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)
Synonyms	DECTIN2 CLECSF10
Description	FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas . Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). .
Accessions	ENST00000382073.4 [Q6EIG7-1] Q6EIG7

CLEC6A report