Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 43 studies | 44% ± 17% | |
| endothelial cell of lymphatic vessel | 21 studies | 34% ± 12% | |
| capillary endothelial cell | 16 studies | 51% ± 18% | |
| endothelial cell of artery | 15 studies | 51% ± 22% | |
| vein endothelial cell | 12 studies | 45% ± 21% | |
| endothelial cell of vascular tree | 10 studies | 32% ± 14% | |
| pericyte | 4 studies | 34% ± 16% | |
| glomerular endothelial cell | 3 studies | 44% ± 3% | |
| endothelial cell of sinusoid | 3 studies | 45% ± 36% |
Insufficient scRNA-seq data for expression of CDH5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 13827.78 | 459 / 459 | 97% | 27.31 | 1088 / 1118 |
| thymus | 100% | 7799.32 | 653 / 653 | 97% | 37.44 | 588 / 605 |
| lung | 100% | 18426.93 | 578 / 578 | 95% | 20.70 | 1092 / 1155 |
| adrenal gland | 95% | 2474.69 | 246 / 258 | 93% | 27.75 | 215 / 230 |
| intestine | 93% | 3145.62 | 894 / 966 | 90% | 16.15 | 475 / 527 |
| kidney | 97% | 3119.08 | 86 / 89 | 85% | 62.46 | 767 / 901 |
| bladder | 95% | 3797.24 | 20 / 21 | 86% | 13.38 | 433 / 504 |
| stomach | 78% | 1883.52 | 279 / 359 | 94% | 21.20 | 268 / 286 |
| esophagus | 82% | 3306.13 | 1189 / 1445 | 89% | 18.22 | 162 / 183 |
| prostate | 85% | 2253.74 | 209 / 245 | 84% | 10.78 | 424 / 502 |
| uterus | 98% | 4164.62 | 167 / 170 | 66% | 11.40 | 304 / 459 |
| skin | 61% | 1852.97 | 1111 / 1809 | 89% | 14.22 | 419 / 472 |
| brain | 47% | 1054.40 | 1252 / 2642 | 95% | 16.14 | 673 / 705 |
| liver | 31% | 598.89 | 70 / 226 | 86% | 15.16 | 351 / 406 |
| ovary | 44% | 1150.98 | 79 / 180 | 71% | 7.34 | 305 / 430 |
| pancreas | 17% | 276.65 | 56 / 328 | 97% | 23.47 | 173 / 178 |
| adipose | 100% | 16123.67 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 6406.81 | 857 / 861 | 0% | 0 | 0 / 0 |
| spleen | 96% | 3144.35 | 232 / 241 | 0% | 0 | 0 / 0 |
| muscle | 96% | 2948.47 | 771 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 76% | 2698.29 | 1019 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 9.05 | 33 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 8.35 | 20 / 29 |
| eye | 0% | 0 | 0 / 0 | 24% | 1.93 | 19 / 80 |
| peripheral blood | 0% | 3.18 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007043 | Biological process | cell-cell junction assembly |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0034332 | Biological process | adherens junction organization |
| GO_0001955 | Biological process | blood vessel maturation |
| GO_2000114 | Biological process | regulation of establishment of cell polarity |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_1903142 | Biological process | positive regulation of establishment of endothelial barrier |
| GO_0043114 | Biological process | regulation of vascular permeability |
| GO_0031115 | Biological process | negative regulation of microtubule polymerization |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0007275 | Biological process | multicellular organism development |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0044331 | Biological process | cell-cell adhesion mediated by cadherin |
| GO_1902396 | Biological process | protein localization to bicellular tight junction |
| GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
| GO_0043534 | Biological process | blood vessel endothelial cell migration |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO_0070830 | Biological process | bicellular tight junction assembly |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0016339 | Biological process | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO_0035633 | Biological process | maintenance of blood-brain barrier |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0016477 | Biological process | cell migration |
| GO_0035307 | Biological process | positive regulation of protein dephosphorylation |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016342 | Cellular component | catenin complex |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0009986 | Cellular component | cell surface |
| GO_0005912 | Cellular component | adherens junction |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0030054 | Cellular component | cell junction |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0070051 | Molecular function | fibrinogen binding |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_1990782 | Molecular function | protein tyrosine kinase binding |
| GO_0043184 | Molecular function | vascular endothelial growth factor receptor 2 binding |
| GO_0070700 | Molecular function | BMP receptor binding |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CDH5 |
| Protein name | Cadherin 5 Cadherin-5 (Vascular endothelial cadherin) Cadherin 5 (cDNA FLJ51088, highly similar to Cadherin-5) Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) |
| Synonyms | |
| Description | FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types . This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton . Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B . Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction . . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. . FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. . |
| Accessions | ENST00000649567.1 [P33151-1] P33151 ENST00000563425.2 Q4VAI4 ENST00000568023.1 I3L1J2 ENST00000539168.1 H3BPG1 ENST00000341529.8 [P33151-1] B4DTR2 H3BR11 ENST00000565334.5 H3BR64 ENST00000568155.2 H3BQ82 ENST00000562048.5 |
