ICOSLG | OmnibusX

Name	Number of supported studies	Average coverage
B cell	3 studies	25% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ICOSLG at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	88%	168.07	78 / 89	18%	0.27	166 / 901
breast	75%	85.86	344 / 459	19%	0.34	209 / 1118
stomach	68%	70.41	243 / 359	23%	0.37	66 / 286
esophagus	55%	64.14	795 / 1445	34%	0.62	62 / 183
lung	79%	92.11	458 / 578	9%	0.17	106 / 1155
prostate	78%	98.10	192 / 245	8%	0.10	40 / 502
brain	67%	103.78	1781 / 2642	18%	0.33	128 / 705
thymus	70%	72.44	458 / 653	6%	0.10	39 / 605
bladder	67%	69.33	14 / 21	10%	0.19	48 / 504
spleen	75%	94.78	181 / 241	0%	0	0 / 0
adipose	73%	79.24	878 / 1204	0%	0	0 / 0
intestine	57%	50.29	549 / 966	16%	0.24	83 / 527
skin	66%	133.55	1190 / 1809	6%	0.10	27 / 472
uterus	60%	46.38	102 / 170	7%	0.13	34 / 459
heart	62%	63.67	538 / 861	0%	0	0 / 0
liver	56%	39.38	126 / 226	6%	0.09	23 / 406
peripheral blood	59%	108.16	545 / 929	0%	0	0 / 0
adrenal gland	54%	33.04	140 / 258	2%	0.04	5 / 230
blood vessel	46%	29.55	610 / 1335	0%	0	0 / 0
ovary	24%	11.99	44 / 180	18%	0.33	76 / 430
lymph node	0%	0	0 / 0	41%	1.17	12 / 29
pancreas	30%	12.39	100 / 328	10%	0.17	18 / 178
tonsil	0%	0	0 / 0	33%	0.81	15 / 45
muscle	33%	19.62	263 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0002250	Biological process	adaptive immune response
GO_0042104	Biological process	positive regulation of activated T cell proliferation
GO_0006972	Biological process	hyperosmotic response
GO_0001817	Biological process	regulation of cytokine production
GO_0042113	Biological process	B cell activation
GO_0042110	Biological process	T cell activation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0006952	Biological process	defense response
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0070062	Cellular component	extracellular exosome
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0042802	Molecular function	identical protein binding

Gene name	ICOSLG
Protein name	Inducible T cell costimulator ligand (Inducible T-cell co-stimulator ligand, isoform CRA_b) ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275) Inducible T cell costimulator ligand Inducible T-cell co-stimulator ligand (cDNA FLJ77643, highly similar to Homo sapiens B7-like protein (B7H2), mRNA) (cDNA, FLJ95137, Homo sapiens B7-like protein (B7H2), mRNA) Inducible T cell costimulator ligand (cDNA FLJ50464, highly similar to ICOS ligand)
Synonyms	hCG_401312 KIAA0653 B7RP1 ICOSL B7H2
Description	FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). .
Accessions	A0A096LPE5 A0A8V8TQ73 ENST00000643466.2 A0A8V8TQV9 O75144 ENST00000407780.8 [O75144-1] A0A8V8TQ42 ENST00000400379.8 ENST00000700355.1 ENST00000700350.1 ENST00000700358.1 ENST00000344330.9 [O75144-2] A0A8V8TQW2 ENST00000700359.1 ENST00000400377.4 [O75144-3] A0N0L8 ENST00000700360.1 ENST00000700352.1 A0A2R8Y5W7 A0A8V8TR62 ENST00000700361.1 K4DIA0 ENST00000700356.1 B7Z1W8 ENST00000700357.1

ICOSLG report