LDLR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	29% ± 12%	Explore
basal cell	14 studies	29% ± 7%	Explore
epithelial cell	13 studies	30% ± 18%	Explore
type II pneumocyte	11 studies	47% ± 17%	Explore
classical monocyte	11 studies	21% ± 6%	Explore
type I pneumocyte	10 studies	40% ± 15%	Explore
secretory cell	9 studies	28% ± 8%	Explore
endothelial cell of vascular tree	9 studies	26% ± 9%	Explore
ciliated cell	8 studies	28% ± 12%	Explore
fibroblast	7 studies	21% ± 5%	Explore
club cell	7 studies	36% ± 13%	Explore
endothelial cell of artery	7 studies	22% ± 7%	Explore
smooth muscle cell	7 studies	23% ± 7%	Explore
goblet cell	7 studies	33% ± 19%	Explore
monocyte	6 studies	21% ± 9%	Explore
adipocyte	6 studies	32% ± 11%	Explore
pericyte	6 studies	23% ± 8%	Explore
hepatocyte	5 studies	42% ± 28%	Explore
T cell	4 studies	26% ± 5%	Explore
ionocyte	4 studies	25% ± 9%	Explore
retinal ganglion cell	4 studies	38% ± 16%	Explore
retinal pigment epithelial cell	4 studies	32% ± 16%	Explore
respiratory goblet cell	4 studies	35% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 5%	Explore
vein endothelial cell	4 studies	25% ± 5%	Explore
natural killer cell	3 studies	18% ± 3%	Explore
myeloid cell	3 studies	22% ± 3%	Explore
duct epithelial cell	3 studies	31% ± 13%	Explore
cholangiocyte	3 studies	46% ± 26%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 6%	Explore
pancreatic A cell	3 studies	31% ± 11%	Explore
pancreatic ductal cell	3 studies	51% ± 20%	Explore
macrophage	3 studies	20% ± 2%	Explore
abnormal cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	10 studies	23% ± 8%	Explore
uterus	3 studies	32% ± 8%	Explore
liver	3 studies	26% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	11644.77	572 / 578	98%	52.83	1129 / 1155
esophagus	95%	6684.39	1369 / 1445	99%	91.19	182 / 183
liver	98%	6168.49	221 / 226	95%	35.54	386 / 406
stomach	93%	5702.32	334 / 359	99%	59.12	282 / 286
intestine	89%	4256.57	864 / 966	99%	65.32	524 / 527
prostate	94%	3417.83	231 / 245	94%	36.16	471 / 502
uterus	96%	4927.89	164 / 170	91%	46.92	418 / 459
breast	96%	4124.15	439 / 459	91%	29.25	1014 / 1118
bladder	95%	4729.67	20 / 21	84%	35.92	423 / 504
pancreas	77%	2397.12	251 / 328	96%	80.44	171 / 178
ovary	99%	8970.15	178 / 180	73%	17.56	314 / 430
adrenal gland	100%	26944.32	258 / 258	69%	109.02	159 / 230
skin	100%	6232.53	1805 / 1809	63%	21.71	299 / 472
thymus	75%	1974.94	489 / 653	51%	10.54	306 / 605
brain	49%	988.20	1287 / 2642	64%	12.41	452 / 705
kidney	76%	2401.91	68 / 89	25%	5.67	221 / 901
tonsil	0%	0	0 / 0	96%	64.55	43 / 45
adipose	94%	6325.11	1127 / 1204	0%	0	0 / 0
spleen	90%	2191.48	217 / 241	0%	0	0 / 0
blood vessel	77%	2937.73	1025 / 1335	0%	0	0 / 0
heart	72%	2562.81	624 / 861	0%	0	0 / 0
peripheral blood	42%	1459.62	386 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	28%	3.21	8 / 29
muscle	7%	112.56	56 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.22	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0090181	Biological process	regulation of cholesterol metabolic process
GO_0048844	Biological process	artery morphogenesis
GO_0006897	Biological process	endocytosis
GO_0015914	Biological process	phospholipid transport
GO_0030299	Biological process	intestinal cholesterol absorption
GO_0010629	Biological process	negative regulation of gene expression
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0007616	Biological process	long-term memory
GO_0034381	Biological process	plasma lipoprotein particle clearance
GO_0061889	Biological process	negative regulation of astrocyte activation
GO_0010989	Biological process	negative regulation of low-density lipoprotein particle clearance
GO_0010628	Biological process	positive regulation of gene expression
GO_0008203	Biological process	cholesterol metabolic process
GO_1903979	Biological process	negative regulation of microglial cell activation
GO_0010867	Biological process	positive regulation of triglyceride biosynthetic process
GO_0042632	Biological process	cholesterol homeostasis
GO_0097242	Biological process	amyloid-beta clearance
GO_0051248	Biological process	negative regulation of protein metabolic process
GO_0046718	Biological process	symbiont entry into host cell
GO_0034384	Biological process	high-density lipoprotein particle clearance
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0042159	Biological process	lipoprotein catabolic process
GO_0070508	Biological process	cholesterol import
GO_0061771	Biological process	response to caloric restriction
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0150094	Biological process	amyloid-beta clearance by cellular catabolic process
GO_1905907	Biological process	negative regulation of amyloid fibril formation
GO_0090118	Biological process	receptor-mediated endocytosis involved in cholesterol transport
GO_0006909	Biological process	phagocytosis
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0010899	Biological process	regulation of phosphatidylcholine catabolic process
GO_0051246	Biological process	regulation of protein metabolic process
GO_0001920	Biological process	negative regulation of receptor recycling
GO_0006629	Biological process	lipid metabolic process
GO_1905167	Biological process	positive regulation of lysosomal protein catabolic process
GO_0030301	Biological process	cholesterol transport
GO_0071398	Biological process	cellular response to fatty acid
GO_1990666	Cellular component	PCSK9-LDLR complex
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0036477	Cellular component	somatodendritic compartment
GO_0005764	Cellular component	lysosome
GO_0034362	Cellular component	low-density lipoprotein particle
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0097443	Cellular component	sorting endosome
GO_0009986	Cellular component	cell surface
GO_0005770	Cellular component	late endosome
GO_0010008	Cellular component	endosome membrane
GO_0005905	Cellular component	clathrin-coated pit
GO_0045177	Cellular component	apical part of cell
GO_0016323	Cellular component	basolateral plasma membrane
GO_0036020	Cellular component	endolysosome membrane
GO_0060090	Molecular function	molecular adaptor activity
GO_0032050	Molecular function	clathrin heavy chain binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0071813	Molecular function	lipoprotein particle binding
GO_0042802	Molecular function	identical protein binding
GO_0001618	Molecular function	virus receptor activity
GO_0002020	Molecular function	protease binding
GO_0005041	Molecular function	low-density lipoprotein particle receptor activity
GO_0030169	Molecular function	low-density lipoprotein particle binding
GO_0030229	Molecular function	very-low-density lipoprotein particle receptor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LDLR
Protein name	Low density lipoprotein receptor Low density lipoprotein Low-density lipoprotein receptor Low-density lipoprotein receptor (LDL receptor) LDLR
Synonyms
Description	FUNCTION: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization . .; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. .; FUNCTION: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. . FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. . FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. .
Accessions	A0A6J4DGZ0 ENST00000557933.5 J3KMZ9 ENST00000252444.10 H0YM92 Q9UH51 E1B4T0 ENST00000558518.6 [P01130-1] A2SZX1 E1B4S5 ENST00000455727.6 [P01130-3] ENST00000560467.2 E2J5K4 A0A0E3MS57 ENST00000535915.5 [P01130-4] H0YMD1 A0A0E3KII0 ENST00000545707.5 [P01130-2] ENST00000558013.5 [P01130-5] A0A5B8PB45 ENST00000559340.2 H0YMQ3 P01130

LDLR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review