Name | PCSK9-LDLR complex |
ID | GO_1990666 |
collection_id | Cellular component |
Exact synonym | PCSK9.LDLR complex, PCSK9/LDL-R complex, PCSK9:low-density lipoprotein receptor complex |
Description | A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. |
Related synonym | PCSK9:EGF-A complex |
External URL | |
Genes |