PCSK9-LDLR complex

I. Literature review

[source]
NamePCSK9-LDLR complex
IDGO_1990666
collection_id

Cellular component

Exact synonym

PCSK9.LDLR complex, PCSK9/LDL-R complex, PCSK9:low-density lipoprotein receptor complex

Description

A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.

Related synonym

PCSK9:EGF-A complex

External URL
Genes