PCSK9 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PCSK9 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PCSK9 at tissue level.

III. Associated gene sets

GO_1905596Biological processnegative regulation of low-density lipoprotein particle receptor binding
GO_0010469Biological processregulation of signaling receptor activity
GO_0032869Biological processcellular response to insulin stimulus
GO_0007041Biological processlysosomal transport
GO_0010989Biological processnegative regulation of low-density lipoprotein particle clearance
GO_0008203Biological processcholesterol metabolic process
GO_0016540Biological processprotein autoprocessing
GO_0032802Biological processlow-density lipoprotein particle receptor catabolic process
GO_0001822Biological processkidney development
GO_0001889Biological processliver development
GO_1905598Biological processnegative regulation of low-density lipoprotein receptor activity
GO_0009267Biological processcellular response to starvation
GO_0042157Biological processlipoprotein metabolic process
GO_0002092Biological processpositive regulation of receptor internalization
GO_0043523Biological processregulation of neuron apoptotic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0030182Biological processneuron differentiation
GO_0022008Biological processneurogenesis
GO_0006641Biological processtriglyceride metabolic process
GO_0032805Biological processpositive regulation of low-density lipoprotein particle receptor catabolic process
GO_0006915Biological processapoptotic process
GO_0006644Biological processphospholipid metabolic process
GO_0002091Biological processnegative regulation of receptor internalization
GO_1905601Biological processnegative regulation of receptor-mediated endocytosis involved in cholesterol transport
GO_0001920Biological processnegative regulation of receptor recycling
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_0042632Biological processcholesterol homeostasis
GO_1990666Cellular componentPCSK9-LDLR complex
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0005794Cellular componentGolgi apparatus
GO_1990667Cellular componentPCSK9-AnxA2 complex
GO_0031232Cellular componentextrinsic component of external side of plasma membrane
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0005765Cellular componentlysosomal membrane
GO_0036020Cellular componentendolysosome membrane
GO_0034190Molecular functionapolipoprotein receptor binding
GO_0030547Molecular functionsignaling receptor inhibitor activity
GO_0034185Molecular functionapolipoprotein binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0019871Molecular functionsodium channel inhibitor activity
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0003723Molecular functionRNA binding
GO_0070326Molecular functionvery-low-density lipoprotein particle receptor binding
GO_0034189Molecular functionvery-low-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePCSK9
Protein nameProprotein convertase subtilisin/kexin type 9 (Proprotein convertase 9) (Subtilisin/kexin-like protease PC9)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Proprotein convertase subtilisin/kexin type 9
SynonymsPSEC0052
NARC1
DescriptionFUNCTION: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments . Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation . Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway . Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. .

AccessionsA0A669KAY4
Q8NBP7
A0A669KB81
ENST00000302118.5 [Q8NBP7-1]
ENST00000673903.1
A0A669KBG0
ENST00000673726.1
ENST00000673913.2
A0AA34QVH0
ENST00000710286.1