P4HB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	40 studies	46% ± 21%	Explore
endothelial cell	37 studies	38% ± 16%	Explore
macrophage	36 studies	39% ± 14%	Explore
natural killer cell	36 studies	41% ± 15%	Explore
pericyte	28 studies	40% ± 20%	Explore
CD8-positive, alpha-beta T cell	28 studies	36% ± 17%	Explore
CD4-positive, alpha-beta T cell	27 studies	34% ± 17%	Explore
T cell	26 studies	33% ± 10%	Explore
plasma cell	26 studies	57% ± 24%	Explore
conventional dendritic cell	24 studies	38% ± 15%	Explore
smooth muscle cell	23 studies	36% ± 14%	Explore
classical monocyte	23 studies	41% ± 15%	Explore
plasmacytoid dendritic cell	22 studies	60% ± 17%	Explore
epithelial cell	22 studies	53% ± 22%	Explore
B cell	21 studies	23% ± 8%	Explore
connective tissue cell	21 studies	46% ± 22%	Explore
basal cell	20 studies	47% ± 19%	Explore
regulatory T cell	19 studies	33% ± 12%	Explore
monocyte	18 studies	38% ± 13%	Explore
endothelial cell of lymphatic vessel	18 studies	35% ± 16%	Explore
mature NK T cell	18 studies	36% ± 10%	Explore
non-classical monocyte	18 studies	32% ± 15%	Explore
gamma-delta T cell	17 studies	38% ± 13%	Explore
dendritic cell	16 studies	38% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	45% ± 10%	Explore
memory B cell	15 studies	21% ± 6%	Explore
mast cell	14 studies	27% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	38% ± 14%	Explore
mucosal invariant T cell	14 studies	38% ± 15%	Explore
ciliated cell	14 studies	36% ± 15%	Explore
capillary endothelial cell	13 studies	32% ± 15%	Explore
myofibroblast cell	13 studies	49% ± 13%	Explore
naive B cell	13 studies	21% ± 4%	Explore
myeloid cell	13 studies	48% ± 20%	Explore
plasmablast	12 studies	71% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	36% ± 13%	Explore
secretory cell	12 studies	44% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	26% ± 5%	Explore
endothelial cell of artery	12 studies	37% ± 14%	Explore
goblet cell	12 studies	51% ± 19%	Explore
vein endothelial cell	12 studies	36% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	37% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 8%	Explore
endothelial cell of vascular tree	11 studies	26% ± 10%	Explore
type I pneumocyte	10 studies	46% ± 19%	Explore
type II pneumocyte	10 studies	52% ± 22%	Explore
club cell	10 studies	46% ± 18%	Explore
abnormal cell	10 studies	50% ± 22%	Explore
mesothelial cell	10 studies	57% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	35% ± 14%	Explore
progenitor cell	9 studies	65% ± 19%	Explore
IgG plasma cell	9 studies	44% ± 13%	Explore
IgA plasma cell	8 studies	46% ± 15%	Explore
alveolar macrophage	7 studies	32% ± 4%	Explore
respiratory goblet cell	7 studies	53% ± 20%	Explore
leukocyte	7 studies	31% ± 11%	Explore
neuron	7 studies	35% ± 14%	Explore
enterocyte	7 studies	59% ± 24%	Explore
T follicular helper cell	7 studies	26% ± 5%	Explore
hematopoietic precursor cell	6 studies	56% ± 15%	Explore
ionocyte	6 studies	44% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	44% ± 20%	Explore
mononuclear phagocyte	6 studies	35% ± 18%	Explore
innate lymphoid cell	6 studies	33% ± 9%	Explore
astrocyte	6 studies	25% ± 10%	Explore
mucus secreting cell	6 studies	49% ± 19%	Explore
adipocyte	6 studies	25% ± 14%	Explore
hepatocyte	6 studies	52% ± 28%	Explore
exhausted T cell	5 studies	42% ± 12%	Explore
platelet	5 studies	20% ± 5%	Explore
epithelial cell of proximal tubule	5 studies	32% ± 17%	Explore
transit amplifying cell	5 studies	51% ± 26%	Explore
erythroblast	5 studies	40% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	47% ± 21%	Explore
erythrocyte	5 studies	39% ± 22%	Explore
duct epithelial cell	4 studies	60% ± 19%	Explore
squamous epithelial cell	4 studies	61% ± 15%	Explore
pancreatic A cell	4 studies	63% ± 13%	Explore
type B pancreatic cell	4 studies	73% ± 14%	Explore
kidney loop of Henle epithelial cell	4 studies	31% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	37% ± 6%	Explore
enteroendocrine cell	4 studies	65% ± 15%	Explore
hematopoietic stem cell	4 studies	34% ± 5%	Explore
lymphocyte	4 studies	41% ± 20%	Explore
megakaryocyte	4 studies	32% ± 7%	Explore
precursor B cell	4 studies	30% ± 6%	Explore
pro-B cell	4 studies	32% ± 6%	Explore
retinal pigment epithelial cell	4 studies	33% ± 19%	Explore
adventitial cell	4 studies	60% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	49% ± 8%	Explore
intermediate monocyte	4 studies	52% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	52% ± 5%	Explore
oligodendrocyte precursor cell	4 studies	30% ± 9%	Explore
keratinocyte	4 studies	39% ± 16%	Explore
T-helper 17 cell	4 studies	40% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	40% ± 7%	Explore
CD4-positive helper T cell	3 studies	23% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	43% ± 25%	Explore
hillock cell	3 studies	56% ± 20%	Explore
precursor cell	3 studies	67% ± 6%	Explore
pancreatic D cell	3 studies	68% ± 13%	Explore
glomerular endothelial cell	3 studies	28% ± 3%	Explore
podocyte	3 studies	53% ± 11%	Explore
renal alpha-intercalated cell	3 studies	36% ± 11%	Explore
intestinal crypt stem cell	3 studies	57% ± 11%	Explore
neural crest cell	3 studies	43% ± 0%	Explore
extravillous trophoblast	3 studies	97% ± 1%	Explore
placental villous trophoblast	3 studies	96% ± 3%	Explore
common myeloid progenitor	3 studies	53% ± 12%	Explore
brush cell	3 studies	27% ± 10%	Explore
neuroendocrine cell	3 studies	51% ± 20%	Explore
immature B cell	3 studies	23% ± 5%	Explore
retina horizontal cell	3 studies	24% ± 9%	Explore
microglial cell	3 studies	33% ± 13%	Explore
serous secreting cell	3 studies	69% ± 8%	Explore
tissue-resident macrophage	3 studies	40% ± 15%	Explore
intraepithelial lymphocyte	3 studies	27% ± 12%	Explore
Mueller cell	3 studies	27% ± 4%	Explore
chondrocyte	3 studies	43% ± 28%	Explore
neutrophil	3 studies	22% ± 2%	Explore
germinal center B cell	3 studies	18% ± 3%	Explore
myoepithelial cell	3 studies	47% ± 17%	Explore
endothelial cell of sinusoid	3 studies	34% ± 10%	Explore
inflammatory macrophage	3 studies	32% ± 10%	Explore
IgM plasma cell	3 studies	50% ± 11%	Explore
muscle cell	3 studies	39% ± 23%	Explore
acinar cell	3 studies	90% ± 10%	Explore
pancreatic ductal cell	3 studies	73% ± 2%	Explore
granulocyte	3 studies	26% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	82% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 25%	Explore
glial cell	3 studies	43% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 12%	Explore
T-helper 1 cell	3 studies	50% ± 20%	Explore
double negative thymocyte	3 studies	52% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	57% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	43% ± 14%	Explore
peripheral blood	17 studies	37% ± 10%	Explore
intestine	12 studies	40% ± 21%	Explore
kidney	8 studies	32% ± 11%	Explore
liver	7 studies	40% ± 17%	Explore
bone marrow	6 studies	34% ± 9%	Explore
brain	6 studies	29% ± 7%	Explore
pancreas	5 studies	63% ± 22%	Explore
eye	5 studies	27% ± 9%	Explore
lymph node	5 studies	35% ± 17%	Explore
placenta	4 studies	71% ± 29%	Explore
uterus	4 studies	45% ± 22%	Explore
prostate	4 studies	27% ± 5%	Explore
breast	4 studies	41% ± 7%	Explore
heart	3 studies	22% ± 9%	Explore
adrenal gland	3 studies	34% ± 9%	Explore
esophagus	3 studies	55% ± 29%	Explore
skin	3 studies	34% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	98341.86	328 / 328	100%	405.60	178 / 178
esophagus	100%	23219.74	1444 / 1445	100%	364.87	183 / 183
prostate	100%	21685.39	245 / 245	100%	853.38	501 / 502
liver	100%	56600.91	226 / 226	100%	710.76	404 / 406
lung	100%	24188.64	576 / 578	100%	532.36	1153 / 1155
skin	100%	40625.00	1809 / 1809	99%	497.29	469 / 472
stomach	100%	27816.61	359 / 359	99%	414.76	284 / 286
breast	100%	18443.20	459 / 459	99%	489.61	1108 / 1118
intestine	100%	17655.18	966 / 966	99%	454.57	522 / 527
ovary	100%	14370.07	180 / 180	99%	272.59	425 / 430
uterus	100%	14986.85	170 / 170	99%	438.55	453 / 459
bladder	100%	17349.76	21 / 21	98%	467.03	494 / 504
thymus	100%	19761.83	653 / 653	97%	266.65	587 / 605
kidney	100%	16056.39	89 / 89	97%	391.57	872 / 901
adrenal gland	100%	34855.95	258 / 258	87%	227.91	201 / 230
brain	64%	4009.57	1693 / 2642	91%	155.99	642 / 705
adipose	100%	19093.94	1204 / 1204	0%	0	0 / 0
spleen	100%	28696.81	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	377.58	45 / 45
ureter	0%	0	0 / 0	100%	174.55	1 / 1
muscle	100%	16596.43	801 / 803	0%	0	0 / 0
blood vessel	100%	22051.25	1330 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	277.55	79 / 80
peripheral blood	97%	17703.69	902 / 929	0%	0	0 / 0
heart	95%	14851.70	822 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	195.32	27 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0018401	Biological process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO_0098761	Biological process	cellular response to interleukin-7
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0046598	Biological process	positive regulation of viral entry into host cell
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0038155	Biological process	interleukin-23-mediated signaling pathway
GO_0006457	Biological process	protein folding
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_1902175	Biological process	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0035722	Biological process	interleukin-12-mediated signaling pathway
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0006888	Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport
GO_0030070	Biological process	insulin processing
GO_0071456	Biological process	cellular response to hypoxia
GO_0009897	Cellular component	external side of plasma membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005925	Cellular component	focal adhesion
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0016222	Cellular component	procollagen-proline 4-dioxygenase complex
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0034663	Cellular component	endoplasmic reticulum chaperone complex
GO_0042470	Cellular component	melanosome
GO_0030027	Cellular component	lamellipodium
GO_0016972	Molecular function	thiol oxidase activity
GO_0019899	Molecular function	enzyme binding
GO_0015035	Molecular function	protein-disulfide reductase activity
GO_0005178	Molecular function	integrin binding
GO_0003723	Molecular function	RNA binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0003756	Molecular function	protein disulfide isomerase activity
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0004656	Molecular function	procollagen-proline 4-dioxygenase activity

IV. Literature review

[source]

Gene name	P4HB
Protein name	Protein disulfide-isomerase (EC 5.3.4.1) Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) protein disulfide-isomerase (EC 5.3.4.1) Alternative protein P4HB (OK/SW-CL.24) Prolyl 4-hydroxylase subunit beta
Synonyms	ERBA2L PDIA1 PDI OK/SW-cl.24 PO4DB hCG_95895
Description	FUNCTION: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins . At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration . .
Accessions	ENST00000571617.2 ENST00000679366.1 I3L3U6 ENST00000680083.1 ENST00000680914.1 P07237 ENST00000680226.1 ENST00000680732.1 B3KTQ9 A0A7P0T9U6 A0A7P0TA35 Q96C96 A0A7P0TBA3 I3NI03 A0A7P0TB26 A0A7P0T9E3 ENST00000680259.1 A0A7P0T9K9 A0A7P0Z4B2 ENST00000576541.2 ENST00000680191.1 ENST00000680105.1 ENST00000680593.1 ENST00000570907.6 A0A7P0Z476 I3L4M2 ENST00000331483.9 ENST00000679455.1 ENST00000679439.1 ENST00000576052.2 Q8NI86 A0A7P0T8X1 ENST00000439918.7 I3L514 ENST00000679688.1 A0A7P0TAX9 ENST00000680416.1 A0A7P0Z4F8 H7BZ94 ENST00000576390.6 I3L3P5 ENST00000679889.1 ENST00000573778.7 A0A7P0T8C0 ENST00000680909.1 ENST00000681693.1 A0A7P0T8J3 ENST00000681420.1 A0A7P0T940 ENST00000576380.6 A0A7P0Z4S2 ENST00000681030.1 A0A7P0T9S9 ENST00000680846.1 ENST00000681566.1 ENST00000680400.1 ENST00000681760.1 ENST00000681515.1 ENST00000681161.1 A0A7P0TA97 A0A7P0TBP8 ENST00000680847.1 I3L0S0 ENST00000680884.1 ENST00000415593.6 I3L1Y5 A0A7P0T9D6 A0A7P0TA71 ENST00000574914.2 ENST00000681933.1 H0Y3Z3 A0A7P0Z4J0 ENST00000681031.1 ENST00000681020.1 ENST00000575069.6

P4HB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review