GO_0030070 | insulin processing

insulin processing

	Genes	Cell types	No. of supported studies
Group 1	SLC30A8 CPE	type B pancreatic cell pancreatic A cell pancreatic D cell	5 studies
Group 2	PCSK1 P4HB PCSK2 YIPF5	dopaminergic neuron type B pancreatic cell glutamatergic neuron	5 studies
Group 3	SLC30A5 ERO1B	dopaminergic neuron glutamatergic neuron GABAergic neuron epithelial cell	12 studies

Name	insulin processing
ID	GO_0030070
collection_id	Biological process
Description	The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.
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Genes	PCSK2 PCSK1 CPE SLC30A5 ERO1B YIPF5 SLC30A8 P4HB