SLC30A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071577Biological processzinc ion transmembrane transport
GO_0062111Biological processzinc ion import into organelle
GO_0006506Biological processGPI anchor biosynthetic process
GO_1904257Biological processzinc ion import into Golgi lumen
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0006829Biological processzinc ion transport
GO_0030070Biological processinsulin processing
GO_0006824Biological processcobalt ion transport
GO_0016324Cellular componentapical plasma membrane
GO_1990674Cellular componentGolgi cis cisterna membrane
GO_0005730Cellular componentnucleolus
GO_0030667Cellular componentsecretory granule membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0030141Cellular componentsecretory granule
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC30A5
Protein nameZinc transporter
Solute carrier family 30 member 5
Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5) (ZnT-like transporter 1) (hZTL1)
SynonymsZTL1
ZNTL1
UNQ863/PRO1879
ZNT5
DescriptionFUNCTION: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway . By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis . Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin . .; FUNCTION: [Isoform 2]: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. .

FUNCTION: Functions as a zinc transporter. .

AccessionsH0YAH4
Q8TAD4
ENST00000513937.1
ENST00000396591.8 [Q8TAD4-1]
ENST00000502979.1 [Q8TAD4-4]
ENST00000504103.5
H0Y957
D6REM2
ENST00000380860.8 [Q8TAD4-3]
ENST00000511158.1