PCSK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0016540Biological processprotein autoprocessing
GO_0007399Biological processnervous system development
GO_0034230Biological processenkephalin processing
GO_0030070Biological processinsulin processing
GO_0006508Biological processproteolysis
GO_0034231Biological processislet amyloid polypeptide processing
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043204Cellular componentperikaryon
GO_0005615Cellular componentextracellular space
GO_0030141Cellular componentsecretory granule
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0043005Cellular componentneuron projection
GO_0016020Cellular componentmembrane
GO_0030133Cellular componenttransport vesicle
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePCSK2
Protein nameNeuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)
SynonymsNEC2
DescriptionFUNCTION: Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. .

AccessionsENST00000377899.5 [P16519-3]
ENST00000536609.1 [P16519-2]
ENST00000262545.7 [P16519-1]
P16519