Name | Number of supported studies | Average coverage | |
---|---|---|---|
GABAergic neuron | 7 studies | 44% ± 21% | |
plasmacytoid dendritic cell | 7 studies | 21% ± 6% | |
glutamatergic neuron | 6 studies | 41% ± 23% | |
naive B cell | 5 studies | 19% ± 3% | |
astrocyte | 5 studies | 29% ± 9% | |
oligodendrocyte precursor cell | 5 studies | 38% ± 12% | |
macrophage | 5 studies | 29% ± 2% | |
interneuron | 5 studies | 48% ± 21% | |
B cell | 4 studies | 21% ± 3% | |
endothelial cell | 4 studies | 20% ± 2% | |
precursor B cell | 4 studies | 27% ± 2% | |
plasma cell | 4 studies | 21% ± 5% | |
oligodendrocyte | 4 studies | 26% ± 2% | |
pancreatic A cell | 3 studies | 40% ± 14% | |
type B pancreatic cell | 3 studies | 73% ± 17% | |
plasmablast | 3 studies | 24% ± 8% | |
pro-B cell | 3 studies | 28% ± 4% | |
myeloid cell | 3 studies | 20% ± 2% | |
gamma-delta T cell | 3 studies | 17% ± 2% | |
dendritic cell | 3 studies | 22% ± 7% | |
enteroendocrine cell | 3 studies | 25% ± 5% | |
brush cell | 3 studies | 23% ± 6% | |
microglial cell | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 36% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 1281.32 | 2623 / 2642 | 100% | 12.78 | 705 / 705 |
thymus | 100% | 2878.02 | 653 / 653 | 99% | 16.82 | 599 / 605 |
prostate | 100% | 1230.08 | 245 / 245 | 99% | 19.41 | 496 / 502 |
kidney | 100% | 1126.83 | 89 / 89 | 98% | 14.00 | 883 / 901 |
liver | 100% | 1870.65 | 226 / 226 | 97% | 22.15 | 394 / 406 |
pancreas | 100% | 18382.48 | 328 / 328 | 96% | 39.00 | 170 / 178 |
adrenal gland | 100% | 1029.33 | 258 / 258 | 90% | 9.99 | 206 / 230 |
lung | 99% | 1149.86 | 574 / 578 | 90% | 13.23 | 1035 / 1155 |
breast | 100% | 1249.56 | 459 / 459 | 89% | 13.56 | 992 / 1118 |
skin | 96% | 621.38 | 1737 / 1809 | 88% | 10.30 | 414 / 472 |
uterus | 99% | 1261.81 | 169 / 170 | 77% | 7.28 | 353 / 459 |
esophagus | 93% | 836.04 | 1338 / 1445 | 83% | 9.25 | 152 / 183 |
bladder | 100% | 1088.24 | 21 / 21 | 75% | 7.03 | 378 / 504 |
stomach | 100% | 7208.17 | 359 / 359 | 59% | 5.52 | 169 / 286 |
ovary | 100% | 1371.18 | 180 / 180 | 52% | 3.08 | 225 / 430 |
intestine | 100% | 1090.61 | 963 / 966 | 50% | 5.02 | 265 / 527 |
spleen | 100% | 1915.45 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.06 | 1 / 1 |
blood vessel | 100% | 1393.41 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 1222.18 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 95% | 704.61 | 818 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 6.57 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 85% | 8.44 | 68 / 80 |
tonsil | 0% | 0 | 0 / 0 | 84% | 13.66 | 38 / 45 |
muscle | 82% | 392.98 | 656 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 69% | 917.07 | 645 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006457 | Biological process | protein folding |
GO_0030070 | Biological process | insulin processing |
GO_0034975 | Biological process | protein folding in endoplasmic reticulum |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0016972 | Molecular function | thiol oxidase activity |
GO_0071949 | Molecular function | FAD binding |
GO_0015035 | Molecular function | protein-disulfide reductase activity |
GO_0051082 | Molecular function | unfolded protein binding |
GO_0016491 | Molecular function | oxidoreductase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ERO1B |
Protein name | Endoplasmic reticulum oxidoreductase 1 beta ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta) |
Synonyms | ERO1LB |
Description | FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. . |
Accessions | ENST00000687487.1 ENST00000354619.10 [Q86YB8-1] A0A8I5KWQ1 Q86YB8 |