ERO1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006457Biological processprotein folding
GO_0030070Biological processinsulin processing
GO_0034975Biological processprotein folding in endoplasmic reticulum
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016972Molecular functionthiol oxidase activity
GO_0071949Molecular functionFAD binding
GO_0015035Molecular functionprotein-disulfide reductase activity
GO_0051082Molecular functionunfolded protein binding
GO_0016491Molecular functionoxidoreductase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERO1B
Protein nameEndoplasmic reticulum oxidoreductase 1 beta
ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)
SynonymsERO1LB
DescriptionFUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis. .

AccessionsENST00000687487.1
ENST00000354619.10 [Q86YB8-1]
A0A8I5KWQ1
Q86YB8