CLEC2D | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	39 studies	42% ± 12%	Explore
B cell	38 studies	33% ± 13%	Explore
T cell	36 studies	37% ± 12%	Explore
CD4-positive, alpha-beta T cell	33 studies	40% ± 14%	Explore
regulatory T cell	27 studies	38% ± 12%	Explore
natural killer cell	22 studies	31% ± 10%	Explore
naive B cell	19 studies	37% ± 9%	Explore
gamma-delta T cell	17 studies	38% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	39% ± 13%	Explore
mature NK T cell	16 studies	36% ± 9%	Explore
memory B cell	14 studies	22% ± 6%	Explore
mucosal invariant T cell	14 studies	31% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	43% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	46% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	48% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	36% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	24% ± 8%	Explore
T follicular helper cell	9 studies	40% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	37% ± 10%	Explore
leukocyte	7 studies	41% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	28% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	43% ± 7%	Explore
precursor B cell	6 studies	37% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 14%	Explore
microglial cell	6 studies	27% ± 6%	Explore
plasmablast	5 studies	50% ± 22%	Explore
dendritic cell	5 studies	18% ± 3%	Explore
macrophage	5 studies	36% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	40% ± 9%	Explore
plasma cell	4 studies	31% ± 12%	Explore
exhausted T cell	4 studies	46% ± 12%	Explore
endothelial cell	4 studies	25% ± 3%	Explore
immature B cell	4 studies	38% ± 4%	Explore
pro-B cell	4 studies	32% ± 6%	Explore
lymphocyte	4 studies	52% ± 20%	Explore
myeloid cell	4 studies	21% ± 6%	Explore
CD4-positive helper T cell	4 studies	45% ± 8%	Explore
T-helper 17 cell	4 studies	42% ± 9%	Explore
T-helper 1 cell	4 studies	47% ± 10%	Explore
germinal center B cell	3 studies	37% ± 9%	Explore
glutamatergic neuron	3 studies	18% ± 2%	Explore
astrocyte	3 studies	20% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 8%	Explore
double negative thymocyte	3 studies	44% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	35% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	28% ± 13%	Explore
lung	7 studies	19% ± 5%	Explore
lymph node	4 studies	28% ± 11%	Explore
bone marrow	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1094.89	457 / 459	99%	6.38	1104 / 1118
lung	100%	1618.53	578 / 578	98%	5.63	1128 / 1155
uterus	100%	1258.07	170 / 170	97%	4.38	445 / 459
ovary	100%	1168.71	180 / 180	96%	3.43	412 / 430
thymus	99%	997.18	646 / 653	94%	5.56	567 / 605
bladder	100%	1060.48	21 / 21	91%	4.56	457 / 504
skin	95%	524.44	1717 / 1809	94%	6.49	444 / 472
esophagus	97%	607.40	1401 / 1445	92%	3.98	168 / 183
prostate	100%	1497.51	245 / 245	87%	2.43	435 / 502
kidney	92%	622.09	82 / 89	88%	5.19	795 / 901
intestine	99%	1478.15	958 / 966	72%	2.23	378 / 527
stomach	94%	524.38	339 / 359	76%	2.74	216 / 286
brain	51%	167.36	1348 / 2642	97%	3.88	683 / 705
pancreas	53%	184.19	175 / 328	93%	5.58	165 / 178
adrenal gland	69%	259.65	177 / 258	47%	0.81	107 / 230
liver	58%	199.06	131 / 226	50%	1.41	205 / 406
lymph node	0%	0	0 / 0	100%	33.57	29 / 29
spleen	100%	4977.57	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.55	1 / 1
adipose	99%	1050.44	1196 / 1204	0%	0	0 / 0
peripheral blood	99%	4004.74	919 / 929	0%	0	0 / 0
blood vessel	93%	588.68	1240 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	6.48	41 / 45
heart	86%	571.54	738 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	54%	1.76	43 / 80
muscle	25%	76.71	200 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009986	Cellular component	cell surface
GO_0009897	Cellular component	external side of plasma membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0030246	Molecular function	carbohydrate binding

IV. Literature review

[source]

Gene name	CLEC2D
Protein name	C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin) Alternative protein CLEC2D C-type lectin domain family 2 member D isoform 10 (C-type lectin domain family 2 member D isoform 7) C-type lectin domain family 2 member D isoform 9 C-type lectin domain family 2 member D variant 3 C-type lectin domain family 2 member D variant 2 C-type lectin domain family 2 member D variant 4 C-type lectin domain family 2 member D isoform 11 C-type lectin domain family 2 member D variant 1 C-type lectin domain family 2 member D isoform 12 C-type lectin domain family 2 member D C-type lectin domain family 2 member D isoform 8
Synonyms	LLT1 CLAX OCIL
Description	FUNCTION: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis . Inhibits osteoclast formation . Inhibits bone resorption . Modulates the release of interferon-gamma . Binds high molecular weight sulfated glycosaminoglycans . .
Accessions	W8SJH0 ENST00000479877.5 [Q9UHP7-2] W8JE22 ENST00000543300.5 [Q9UHP7-5] ENST00000261339.10 [Q9UHP7-6] ENST00000325960.11 A0A0C4DG81 ENST00000545918.5 [Q9UHP7-7] ENST00000430909.5 ENST00000476198.2 F5H5U4 ENST00000466035.6 W8JXM2 F8WF99 H0YH49 ENST00000544322.1 ENST00000290855.11 [Q9UHP7-1] A0A0C4DGG4 W8SBA0 Q9UHP7 W8T7N2 ENST00000492359.6 ENST00000444971.6 ENST00000460309.1 W8SND9 W8S9T2 W8JD10 ENST00000261340.11 [Q9UHP7-3] ENST00000536355.5 V9HVU7 W8JNK3 H0YGG6 F5H0P0

CLEC2D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review