SLC22A11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC22A11 at tissue level.

III. Associated gene sets

GO_0046415Biological processurate metabolic process
GO_0006811Biological processmonoatomic ion transport
GO_0015732Biological processprostaglandin transport
GO_0015711Biological processorganic anion transport
GO_0055085Biological processtransmembrane transport
GO_0015698Biological processinorganic anion transport
GO_0016324Cellular componentapical plasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015347Molecular functionsodium-independent organic anion transmembrane transporter activity
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC22A11
Protein nameSolute carrier family 22 member 11
Solute carrier family 22 member 11 (Organic anion transporter 4) (OAT4) (Organic anion:dicarboxylate exchanger OAT4)
SynonymsOAT4
DescriptionFUNCTION: Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds . May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus . Maybe also be involved in placental urate homeostasis . Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates . Organic anion glutarate acts as conteranion for E1S renal uptake . Possible transport mode may also include DHEA-S/E1S exchange . Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) . Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion . Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A . Mediates the unidirectional efflux of glutamate and aspartate . Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S . .

AccessionsENST00000377585.7 [Q9NSA0-2]
ENST00000377581.7
ENST00000301891.9 [Q9NSA0-1]
H7C3R9
H7C0B7
ENST00000428570.1
ENST00000416590.1
Q9NSA0
A6NCG2