I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glial cell | 3 studies | 43% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glial cell | 3 studies | 43% ± 11% |
Insufficient scRNA-seq data for expression of GFRA3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 84% | 401.15 | 206 / 245 | 51% | 2.78 | 254 / 502 |
| stomach | 98% | 460.13 | 352 / 359 | 30% | 3.82 | 87 / 286 |
| esophagus | 84% | 862.01 | 1216 / 1445 | 41% | 4.76 | 75 / 183 |
| pancreas | 63% | 95.94 | 206 / 328 | 57% | 4.23 | 102 / 178 |
| bladder | 81% | 463.05 | 17 / 21 | 31% | 7.14 | 158 / 504 |
| intestine | 88% | 768.08 | 847 / 966 | 20% | 2.21 | 107 / 527 |
| adrenal gland | 30% | 45.00 | 78 / 258 | 63% | 62.27 | 146 / 230 |
| skin | 53% | 167.29 | 963 / 1809 | 35% | 17.01 | 166 / 472 |
| ovary | 47% | 96.63 | 85 / 180 | 39% | 5.33 | 169 / 430 |
| uterus | 42% | 147.08 | 72 / 170 | 34% | 5.64 | 156 / 459 |
| lung | 6% | 7.33 | 32 / 578 | 63% | 21.80 | 726 / 1155 |
| heart | 63% | 225.20 | 539 / 861 | 0% | 0 | 0 / 0 |
| breast | 46% | 146.77 | 211 / 459 | 15% | 2.69 | 163 / 1118 |
| thymus | 36% | 66.59 | 235 / 653 | 8% | 5.41 | 47 / 605 |
| adipose | 41% | 124.33 | 499 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 39% | 123.64 | 520 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 31% | 3.18 | 14 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 0.95 | 8 / 29 |
| brain | 19% | 87.06 | 497 / 2642 | 3% | 0.25 | 20 / 705 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.96 | 14 / 80 |
| kidney | 15% | 25.17 | 13 / 89 | 2% | 0.09 | 19 / 901 |
| liver | 6% | 9.10 | 13 / 226 | 6% | 2.55 | 24 / 406 |
| muscle | 2% | 2.16 | 13 / 803 | 0% | 0 | 0 / 0 |
| spleen | 1% | 0.88 | 2 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0007399 | Biological process | nervous system development |
| GO_0001764 | Biological process | neuron migration |
| GO_0007422 | Biological process | peripheral nervous system development |
| GO_0048485 | Biological process | sympathetic nervous system development |
| GO_0007411 | Biological process | axon guidance |
| GO_0035860 | Biological process | glial cell-derived neurotrophic factor receptor signaling pathway |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0019898 | Cellular component | extrinsic component of membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0008046 | Molecular function | axon guidance receptor activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016167 | Molecular function | glial cell-derived neurotrophic factor receptor activity |
| Gene name | GFRA3 |
| Protein name | GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3) |
| Synonyms | UNQ339/PRO538/PRO3664 |
| Description | FUNCTION: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. . |
| Accessions | O60609 ENST00000274721.8 [O60609-1] ENST00000378362.3 [O60609-2] |
