CD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	43 studies	57% ± 18%	Explore
T cell	39 studies	50% ± 18%	Explore
natural killer cell	35 studies	36% ± 11%	Explore
CD4-positive, alpha-beta T cell	35 studies	58% ± 15%	Explore
regulatory T cell	30 studies	63% ± 18%	Explore
mature NK T cell	20 studies	48% ± 17%	Explore
gamma-delta T cell	20 studies	45% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	47% ± 14%	Explore
mucosal invariant T cell	17 studies	46% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	44% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	58% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	62% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	53% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	63% ± 12%	Explore
T follicular helper cell	10 studies	69% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	62% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	64% ± 14%	Explore
CD4-positive helper T cell	6 studies	58% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	48% ± 22%	Explore
leukocyte	6 studies	42% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	69% ± 9%	Explore
innate lymphoid cell	6 studies	43% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	61% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	54% ± 21%	Explore
exhausted T cell	5 studies	77% ± 8%	Explore
lymphocyte	5 studies	37% ± 14%	Explore
group 3 innate lymphoid cell	4 studies	34% ± 9%	Explore
T-helper 17 cell	4 studies	77% ± 12%	Explore
T-helper 1 cell	4 studies	84% ± 9%	Explore
double negative thymocyte	4 studies	44% ± 5%	Explore
plasmacytoid dendritic cell	3 studies	23% ± 4%	Explore
conventional dendritic cell	3 studies	28% ± 6%	Explore
thymocyte	3 studies	36% ± 7%	Explore
intraepithelial lymphocyte	3 studies	51% ± 22%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	61% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	31% ± 8%	Explore
lung	5 studies	30% ± 8%	Explore
lymph node	4 studies	31% ± 12%	Explore
bone marrow	3 studies	28% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	663.35	578 / 578	92%	36.08	1058 / 1155
stomach	90%	326.11	322 / 359	79%	26.33	225 / 286
thymus	93%	301.64	610 / 653	69%	82.71	417 / 605
prostate	89%	232.90	217 / 245	68%	13.17	339 / 502
intestine	68%	558.95	657 / 966	78%	20.30	411 / 527
breast	65%	114.62	298 / 459	81%	36.35	904 / 1118
uterus	67%	93.44	114 / 170	75%	29.45	342 / 459
kidney	58%	149.11	52 / 89	76%	33.40	688 / 901
bladder	67%	233.43	14 / 21	64%	19.27	325 / 504
esophagus	58%	128.87	833 / 1445	66%	16.64	121 / 183
liver	70%	92.80	158 / 226	48%	12.49	195 / 406
pancreas	33%	37.23	107 / 328	81%	26.97	144 / 178
lymph node	0%	0	0 / 0	100%	192.03	29 / 29
spleen	100%	2485.77	241 / 241	0%	0	0 / 0
skin	28%	32.76	513 / 1809	69%	42.42	328 / 472
tonsil	0%	0	0 / 0	93%	69.73	42 / 45
peripheral blood	87%	2098.57	806 / 929	0%	0	0 / 0
adipose	86%	182.57	1037 / 1204	0%	0	0 / 0
ovary	20%	28.88	36 / 180	56%	11.18	242 / 430
adrenal gland	41%	50.62	105 / 258	14%	1.95	33 / 230
blood vessel	41%	87.58	547 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	20%	6.99	16 / 80
heart	18%	21.97	153 / 861	0%	0	0 / 0
brain	6%	6.76	147 / 2642	12%	1.97	85 / 705
muscle	1%	1.82	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045580	Biological process	regulation of T cell differentiation
GO_0030101	Biological process	natural killer cell activation
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0001766	Biological process	membrane raft polarization
GO_0006915	Biological process	apoptotic process
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0030887	Biological process	positive regulation of myeloid dendritic cell activation
GO_0098609	Biological process	cell-cell adhesion
GO_0042110	Biological process	T cell activation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005911	Cellular component	cell-cell junction
GO_0009986	Cellular component	cell surface
GO_0038023	Molecular function	signaling receptor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

IV. Literature review

[source]

Gene name	CD2
Protein name	T-cell surface antigen CD2 CD2 molecule T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Synonyms	SRBC hCG_39065
Description	FUNCTION: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Accessions	Q5JVN7 ENST00000369478.4 ENST00000369477.1 P06729 Q53F96

CD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review