ITGAM | OmnibusX

Name	Number of supported studies	Average coverage
classical monocyte	21 studies	37% ± 16%	Explore
macrophage	19 studies	24% ± 9%	Explore
monocyte	17 studies	25% ± 9%	Explore
natural killer cell	16 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 11%	Explore
myeloid cell	11 studies	33% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	32% ± 13%	Explore
microglial cell	9 studies	34% ± 13%	Explore
neutrophil	5 studies	25% ± 12%	Explore
non-classical monocyte	5 studies	20% ± 3%	Explore
dendritic cell	5 studies	24% ± 4%	Explore
conventional dendritic cell	4 studies	28% ± 12%	Explore
mature NK T cell	4 studies	20% ± 7%	Explore
mononuclear phagocyte	4 studies	17% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
alveolar macrophage	3 studies	27% ± 7%	Explore
mast cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	27% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3811.33	578 / 578	88%	15.56	1021 / 1155
breast	88%	846.84	403 / 459	93%	15.08	1035 / 1118
bladder	95%	798.24	20 / 21	56%	6.35	282 / 504
brain	58%	407.91	1535 / 2642	91%	12.86	639 / 705
thymus	66%	407.68	433 / 653	80%	7.99	485 / 605
intestine	90%	808.48	866 / 966	55%	5.84	288 / 527
kidney	49%	410.69	44 / 89	88%	13.13	793 / 901
uterus	70%	438.09	119 / 170	61%	5.82	280 / 459
esophagus	69%	577.29	996 / 1445	61%	4.77	112 / 183
adrenal gland	94%	1095.98	243 / 258	35%	2.03	80 / 230
pancreas	33%	206.68	108 / 328	90%	15.20	161 / 178
stomach	58%	450.70	209 / 359	64%	6.09	182 / 286
prostate	67%	427.00	164 / 245	47%	2.53	235 / 502
skin	31%	154.27	565 / 1809	78%	9.56	368 / 472
liver	51%	317.23	115 / 226	51%	5.63	209 / 406
ovary	43%	244.83	77 / 180	59%	5.23	255 / 430
lymph node	0%	0	0 / 0	100%	23.93	29 / 29
spleen	100%	7047.05	241 / 241	0%	0	0 / 0
adipose	99%	2102.24	1194 / 1204	0%	0	0 / 0
peripheral blood	97%	19547.65	900 / 929	0%	0	0 / 0
blood vessel	81%	870.09	1076 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	76%	12.37	34 / 45
heart	70%	518.35	602 / 861	0%	0	0 / 0
muscle	18%	85.43	144 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	10%	0.45	8 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032355	Biological process	response to estradiol
GO_0098742	Biological process	cell-cell adhesion via plasma-membrane adhesion molecules
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0002931	Biological process	response to ischemia
GO_0001774	Biological process	microglial cell activation
GO_0140459	Biological process	response to Gram-positive bacterium
GO_0150062	Biological process	complement-mediated synapse pruning
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0045087	Biological process	innate immune response
GO_0007160	Biological process	cell-matrix adhesion
GO_0030900	Biological process	forebrain development
GO_0150064	Biological process	vertebrate eye-specific patterning
GO_0007155	Biological process	cell adhesion
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0006911	Biological process	phagocytosis, engulfment
GO_0043315	Biological process	positive regulation of neutrophil degranulation
GO_0097242	Biological process	amyloid-beta clearance
GO_0045963	Biological process	negative regulation of dopamine metabolic process
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0090314	Biological process	positive regulation of protein targeting to membrane
GO_1904643	Biological process	response to curcumin
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0009612	Biological process	response to mechanical stimulus
GO_1904151	Biological process	positive regulation of microglial cell mediated cytotoxicity
GO_0098609	Biological process	cell-cell adhesion
GO_0010668	Biological process	ectodermal cell differentiation
GO_2000363	Biological process	positive regulation of prostaglandin-E synthase activity
GO_0002430	Biological process	complement receptor mediated signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0008305	Cellular component	integrin complex
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0044853	Cellular component	plasma membrane raft
GO_0070821	Cellular component	tertiary granule membrane
GO_0034688	Cellular component	integrin alphaM-beta2 complex
GO_0031072	Molecular function	heat shock protein binding
GO_0038024	Molecular function	cargo receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0005178	Molecular function	integrin binding
GO_0046872	Molecular function	metal ion binding
GO_0001851	Molecular function	complement component C3b binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGAM
Protein name	Integrin subunit alpha M Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) Integrin alpha-M
Synonyms	CD11B CR3A
Description	FUNCTION: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens . It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration . In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils . May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). .
Accessions	I3NI33 ENST00000565142.1 H3BMV4 A0A3T1DF60 A0A3T1DFB0 ENST00000567031.1 P11215 ENST00000544665.9 [P11215-1] ENST00000648685.1 [P11215-2]

ITGAM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review