FCN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002752Biological processcell surface pattern recognition receptor signaling pathway
GO_1903028Biological processpositive regulation of opsonization
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0034394Biological processprotein localization to cell surface
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0006508Biological processproteolysis
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0043654Biological processrecognition of apoptotic cell
GO_0001867Biological processcomplement activation, lectin pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005581Cellular componentcollagen trimer
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0038187Molecular functionpattern recognition receptor activity
GO_0033691Molecular functionsialic acid binding
GO_0030246Molecular functioncarbohydrate binding
GO_0005102Molecular functionsignaling receptor binding
GO_0097367Molecular functioncarbohydrate derivative binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0003823Molecular functionantigen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFCN1
Protein nameFicolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)
p35-related protein
SynonymsFCNM
DescriptionFUNCTION: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 . Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. .

AccessionsO00602
ENST00000371806.4
Q92531