Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 29 studies | 85% ± 12% | |
monocyte | 28 studies | 61% ± 26% | |
non-classical monocyte | 28 studies | 78% ± 16% | |
conventional dendritic cell | 19 studies | 40% ± 20% | |
dendritic cell | 12 studies | 40% ± 18% | |
macrophage | 9 studies | 35% ± 14% | |
myeloid cell | 8 studies | 52% ± 25% | |
neutrophil | 7 studies | 70% ± 23% | |
intermediate monocyte | 6 studies | 75% ± 21% | |
mononuclear phagocyte | 4 studies | 37% ± 27% | |
platelet | 3 studies | 45% ± 21% | |
inflammatory macrophage | 3 studies | 45% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 3238.08 | 575 / 578 | 76% | 3.97 | 877 / 1155 |
kidney | 48% | 215.91 | 43 / 89 | 77% | 4.10 | 694 / 901 |
breast | 74% | 362.82 | 338 / 459 | 47% | 1.57 | 527 / 1118 |
liver | 63% | 272.34 | 143 / 226 | 37% | 1.00 | 152 / 406 |
spleen | 100% | 6711.72 | 241 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 8.74 | 28 / 29 |
thymus | 43% | 130.71 | 284 / 653 | 53% | 1.84 | 320 / 605 |
adipose | 93% | 821.20 | 1123 / 1204 | 0% | 0 | 0 / 0 |
bladder | 52% | 386.29 | 11 / 21 | 40% | 1.62 | 204 / 504 |
pancreas | 18% | 81.48 | 58 / 328 | 65% | 4.72 | 116 / 178 |
stomach | 33% | 193.99 | 119 / 359 | 49% | 1.35 | 141 / 286 |
peripheral blood | 81% | 37550.81 | 755 / 929 | 0% | 0 | 0 / 0 |
intestine | 43% | 184.98 | 411 / 966 | 38% | 1.32 | 198 / 527 |
skin | 13% | 32.68 | 232 / 1809 | 66% | 3.45 | 310 / 472 |
prostate | 38% | 160.20 | 94 / 245 | 37% | 0.98 | 188 / 502 |
uterus | 34% | 131.02 | 57 / 170 | 34% | 0.96 | 156 / 459 |
ovary | 11% | 37.88 | 19 / 180 | 51% | 1.71 | 220 / 430 |
adrenal gland | 20% | 53.72 | 52 / 258 | 32% | 0.78 | 73 / 230 |
heart | 51% | 181.94 | 436 / 861 | 0% | 0 | 0 / 0 |
esophagus | 27% | 100.91 | 385 / 1445 | 21% | 0.68 | 39 / 183 |
tonsil | 0% | 0 | 0 / 0 | 42% | 1.33 | 19 / 45 |
blood vessel | 35% | 197.39 | 472 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 15% | 0.27 | 12 / 80 |
brain | 5% | 12.14 | 136 / 2642 | 10% | 0.28 | 69 / 705 |
muscle | 11% | 22.81 | 92 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002752 | Biological process | cell surface pattern recognition receptor signaling pathway |
GO_1903028 | Biological process | positive regulation of opsonization |
GO_0046597 | Biological process | negative regulation of viral entry into host cell |
GO_0034394 | Biological process | protein localization to cell surface |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0006508 | Biological process | proteolysis |
GO_0032757 | Biological process | positive regulation of interleukin-8 production |
GO_0043654 | Biological process | recognition of apoptotic cell |
GO_0001867 | Biological process | complement activation, lectin pathway |
GO_0005615 | Cellular component | extracellular space |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0005581 | Cellular component | collagen trimer |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0034774 | Cellular component | secretory granule lumen |
GO_1904813 | Cellular component | ficolin-1-rich granule lumen |
GO_1905370 | Cellular component | serine-type endopeptidase complex |
GO_0038187 | Molecular function | pattern recognition receptor activity |
GO_0033691 | Molecular function | sialic acid binding |
GO_0030246 | Molecular function | carbohydrate binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0097367 | Molecular function | carbohydrate derivative binding |
GO_0001664 | Molecular function | G protein-coupled receptor binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0003823 | Molecular function | antigen binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FCN1 |
Protein name | Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) p35-related protein |
Synonyms | FCNM |
Description | FUNCTION: Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 . Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. . |
Accessions | O00602 ENST00000371806.4 Q92531 |