FCER1A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FCER1A at tissue level.

III. Associated gene sets

GO_0043303Biological processmast cell degranulation
GO_0042092Biological processtype 2 immune response
GO_0043308Biological processeosinophil degranulation
GO_0016068Biological processtype I hypersensitivity
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009986Cellular componentcell surface
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0019768Molecular functionhigh-affinity IgE receptor activity
GO_0005515Molecular functionprotein binding
GO_0019863Molecular functionIgE binding

IV. Literature review

[source]
Gene nameFCER1A
Protein nameFc of IgE, high affinity I, receptor for alpha polypeptide
Fc epsilon receptor Ia
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
SynonymsFCE1A
DescriptionFUNCTION: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. .

AccessionsENST00000709173.1
ENST00000368114.1
Q6GU38
ENST00000693622.1
ENST00000709171.1
P12319
ENST00000368115.5
E9PRN1