GP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GP2 at tissue level.

III. Associated gene sets

GO_1990266Biological processneutrophil migration
GO_0002412Biological processantigen transcytosis by M cells in mucosal-associated lymphoid tissue
GO_0045087Biological processinnate immune response
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005768Cellular componentendosome
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0042589Cellular componentzymogen granule membrane
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameGP2
Protein namePancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)
Glycoprotein 2 (Zymogen granule membrane)
Glycoprotein 2
Synonyms
DescriptionFUNCTION: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. .

AccessionsENST00000341642.9 [P55259-4]
ENST00000381360.9 [P55259-2]
ENST00000381362.8 [P55259-1]
P55259
ENST00000575582.5
I3L2Z7
ENST00000572347.5
I3L4Y3
I3L486
Q8N1A3
ENST00000575449.1
I3L3I2
ENST00000574982.1
ENST00000302555.10 [P55259-3]
ENST00000572478.5
I3L324