CCR7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	29 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	22 studies	40% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	49% ± 16%	Explore
naive B cell	18 studies	36% ± 12%	Explore
regulatory T cell	16 studies	32% ± 12%	Explore
memory B cell	15 studies	28% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	47% ± 15%	Explore
dendritic cell	11 studies	62% ± 29%	Explore
T cell	10 studies	27% ± 15%	Explore
CD8-positive, alpha-beta T cell	9 studies	44% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	34% ± 11%	Explore
T follicular helper cell	5 studies	34% ± 12%	Explore
innate lymphoid cell	3 studies	28% ± 13%	Explore
conventional dendritic cell	3 studies	26% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	66% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	32% ± 7%	Explore
leukocyte	3 studies	24% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	30% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	21% ± 2%	Explore
lymph node	3 studies	41% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	96%	230.29	557 / 578	84%	9.75	965 / 1155
breast	95%	230.31	434 / 459	77%	11.75	864 / 1118
bladder	86%	183.43	18 / 21	74%	23.96	372 / 504
thymus	97%	285.54	635 / 653	60%	10.73	366 / 605
uterus	80%	151.46	136 / 170	65%	7.38	299 / 459
skin	76%	195.95	1369 / 1809	64%	13.19	303 / 472
intestine	75%	586.17	721 / 966	61%	6.00	323 / 527
prostate	75%	173.18	183 / 245	53%	3.71	265 / 502
ovary	79%	144.04	143 / 180	38%	1.77	164 / 430
stomach	48%	78.48	173 / 359	67%	5.90	192 / 286
esophagus	53%	108.41	768 / 1445	57%	4.89	104 / 183
kidney	38%	97.61	34 / 89	62%	4.10	560 / 901
lymph node	0%	0	0 / 0	100%	245.60	29 / 29
spleen	100%	2303.73	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	151.65	1 / 1
peripheral blood	99%	4845.34	919 / 929	0%	0	0 / 0
adipose	94%	331.46	1130 / 1204	0%	0	0 / 0
liver	64%	94.85	145 / 226	26%	2.98	105 / 406
tonsil	0%	0	0 / 0	89%	22.57	40 / 45
pancreas	12%	10.91	38 / 328	74%	15.92	132 / 178
blood vessel	62%	156.52	829 / 1335	0%	0	0 / 0
adrenal gland	45%	40.90	115 / 258	16%	0.64	37 / 230
heart	50%	106.05	432 / 861	0%	0	0 / 0
brain	7%	7.26	186 / 2642	7%	0.60	50 / 705
muscle	10%	16.39	83 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	8%	0.50	6 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002407	Biological process	dendritic cell chemotaxis
GO_0050862	Biological process	positive regulation of T cell receptor signaling pathway
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_2000522	Biological process	positive regulation of immunological synapse formation
GO_0006954	Biological process	inflammatory response
GO_0031529	Biological process	ruffle organization
GO_0019722	Biological process	calcium-mediated signaling
GO_0032649	Biological process	regulation of type II interferon production
GO_0038115	Biological process	chemokine (C-C motif) ligand 19 signaling pathway
GO_0002885	Biological process	positive regulation of hypersensitivity
GO_0038116	Biological process	chemokine (C-C motif) ligand 21 signaling pathway
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_2000147	Biological process	positive regulation of cell motility
GO_0097022	Biological process	lymphocyte migration into lymph node
GO_0097029	Biological process	mature conventional dendritic cell differentiation
GO_0032695	Biological process	negative regulation of interleukin-12 production
GO_0002606	Biological process	positive regulation of dendritic cell antigen processing and presentation
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0048872	Biological process	homeostasis of number of cells
GO_0002408	Biological process	myeloid dendritic cell chemotaxis
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_2000525	Biological process	positive regulation of T cell costimulation
GO_0002922	Biological process	positive regulation of humoral immune response
GO_0006955	Biological process	immune response
GO_2000510	Biological process	positive regulation of dendritic cell chemotaxis
GO_2000547	Biological process	regulation of dendritic cell dendrite assembly
GO_0001768	Biological process	establishment of T cell polarity
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_2000526	Biological process	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0032651	Biological process	regulation of interleukin-1 beta production
GO_0034695	Biological process	response to prostaglandin E
GO_0071731	Biological process	response to nitric oxide
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0045060	Biological process	negative thymic T cell selection
GO_0031274	Biological process	positive regulation of pseudopodium assembly
GO_2000669	Biological process	negative regulation of dendritic cell apoptotic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0060326	Biological process	cell chemotaxis
GO_0032496	Biological process	response to lipopolysaccharide
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0009986	Cellular component	cell surface
GO_0038117	Molecular function	C-C motif chemokine 19 receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0035758	Molecular function	chemokine (C-C motif) ligand 21 binding
GO_0038121	Molecular function	C-C motif chemokine 21 receptor activity
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0035757	Molecular function	chemokine (C-C motif) ligand 19 binding

IV. Literature review

[source]

Gene name	CCR7
Protein name	Chemokine (C-C motif) receptor 7 (cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7) C-C motif chemokine receptor 7 C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197)
Synonyms	hCG_1643840 EBI1 EVI1 CMKBR7
Description	FUNCTION: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Accessions	J3KTN5 P32248 ENST00000579344.1 A0N0Q0 ENST00000246657.2 ENST00000578085.1 J3KSS9

CCR7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review