EFNA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048013Biological processephrin receptor signaling pathway
GO_0048668Biological processcollateral sprouting
GO_0071372Biological processcellular response to follicle-stimulating hormone stimulus
GO_0022407Biological processregulation of cell-cell adhesion
GO_0022604Biological processregulation of cell morphogenesis
GO_0099560Biological processsynaptic membrane adhesion
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0050919Biological processnegative chemotaxis
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0043087Biological processregulation of GTPase activity
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_1904322Biological processcellular response to forskolin
GO_0051893Biological processregulation of focal adhesion assembly
GO_0006915Biological processapoptotic process
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0048672Biological processpositive regulation of collateral sprouting
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0051965Biological processpositive regulation of synapse assembly
GO_0007399Biological processnervous system development
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0007411Biological processaxon guidance
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0098982Cellular componentGABA-ergic synapse
GO_0005912Cellular componentadherens junction
GO_0005604Cellular componentbasement membrane
GO_0005901Cellular componentcaveola
GO_0046875Molecular functionephrin receptor binding
GO_0005169Molecular functionneurotrophin TRKB receptor binding
GO_0005168Molecular functionneurotrophin TRKA receptor binding
GO_0005170Molecular functionneurotrophin TRKC receptor binding
GO_0045499Molecular functionchemorepellent activity
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEFNA5
Protein nameAlternative protein EFNA5
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
EPH-related receptor tyrosine kinase ligand 7
SynonymsLERK7
EPLG7
DescriptionFUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. .

AccessionsP52803
L8E7B5
D6RDV5
L8E8V0
ENST00000333274.11
ENST00000509503.1