Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell of lymphatic vessel | 20 studies | 44% ± 23% | |
glutamatergic neuron | 13 studies | 61% ± 28% | |
astrocyte | 12 studies | 45% ± 20% | |
mesothelial cell | 10 studies | 48% ± 19% | |
adipocyte | 10 studies | 59% ± 17% | |
fibroblast | 10 studies | 28% ± 11% | |
GABAergic neuron | 9 studies | 45% ± 23% | |
endothelial cell | 8 studies | 38% ± 22% | |
basal cell | 8 studies | 45% ± 22% | |
neuron | 7 studies | 37% ± 15% | |
epithelial cell | 7 studies | 43% ± 24% | |
interneuron | 6 studies | 48% ± 18% | |
cardiac muscle cell | 6 studies | 65% ± 23% | |
ciliated cell | 6 studies | 31% ± 10% | |
amacrine cell | 5 studies | 37% ± 17% | |
retina horizontal cell | 5 studies | 45% ± 24% | |
type II pneumocyte | 5 studies | 50% ± 5% | |
smooth muscle cell | 4 studies | 39% ± 18% | |
pericyte | 4 studies | 32% ± 16% | |
connective tissue cell | 4 studies | 22% ± 4% | |
respiratory goblet cell | 4 studies | 51% ± 18% | |
club cell | 4 studies | 34% ± 11% | |
myofibroblast cell | 3 studies | 24% ± 9% | |
GABAergic interneuron | 3 studies | 40% ± 7% | |
granule cell | 3 studies | 47% ± 9% | |
GABAergic amacrine cell | 3 studies | 49% ± 9% | |
glycinergic amacrine cell | 3 studies | 46% ± 11% | |
retinal pigment epithelial cell | 3 studies | 56% ± 15% | |
mucus secreting cell | 3 studies | 49% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 95% | 564.32 | 550 / 578 | 87% | 14.52 | 1010 / 1155 |
breast | 98% | 1145.45 | 449 / 459 | 79% | 15.21 | 881 / 1118 |
ovary | 83% | 742.67 | 150 / 180 | 90% | 13.92 | 387 / 430 |
skin | 100% | 2326.70 | 1809 / 1809 | 73% | 10.69 | 346 / 472 |
kidney | 100% | 1087.24 | 89 / 89 | 71% | 14.72 | 640 / 901 |
esophagus | 87% | 791.52 | 1261 / 1445 | 83% | 10.08 | 152 / 183 |
prostate | 99% | 1099.93 | 242 / 245 | 68% | 5.32 | 341 / 502 |
bladder | 86% | 589.00 | 18 / 21 | 76% | 9.96 | 381 / 504 |
intestine | 95% | 891.54 | 913 / 966 | 41% | 3.54 | 217 / 527 |
stomach | 95% | 519.53 | 342 / 359 | 39% | 2.90 | 111 / 286 |
brain | 81% | 676.55 | 2132 / 2642 | 39% | 2.85 | 278 / 705 |
uterus | 25% | 212.29 | 42 / 170 | 90% | 15.14 | 412 / 459 |
thymus | 93% | 553.08 | 608 / 653 | 21% | 3.24 | 125 / 605 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.39 | 1 / 1 |
spleen | 99% | 1103.59 | 239 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 1056.90 | 1192 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 1143.91 | 1318 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 4% | 11.32 | 14 / 328 | 94% | 18.02 | 167 / 178 |
heart | 94% | 937.83 | 807 / 861 | 0% | 0 | 0 / 0 |
adrenal gland | 14% | 51.99 | 37 / 258 | 74% | 11.17 | 170 / 230 |
tonsil | 0% | 0 | 0 / 0 | 82% | 8.87 | 37 / 45 |
lymph node | 0% | 0 | 0 / 0 | 28% | 1.94 | 8 / 29 |
liver | 2% | 4.71 | 4 / 226 | 17% | 2.82 | 68 / 406 |
muscle | 10% | 35.33 | 79 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 9% | 91.45 | 80 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 5% | 0.17 | 4 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0048013 | Biological process | ephrin receptor signaling pathway |
GO_0048668 | Biological process | collateral sprouting |
GO_0071372 | Biological process | cellular response to follicle-stimulating hormone stimulus |
GO_0022407 | Biological process | regulation of cell-cell adhesion |
GO_0022604 | Biological process | regulation of cell morphogenesis |
GO_0099560 | Biological process | synaptic membrane adhesion |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0050919 | Biological process | negative chemotaxis |
GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_0061178 | Biological process | regulation of insulin secretion involved in cellular response to glucose stimulus |
GO_1904322 | Biological process | cellular response to forskolin |
GO_0051893 | Biological process | regulation of focal adhesion assembly |
GO_0006915 | Biological process | apoptotic process |
GO_1900025 | Biological process | negative regulation of substrate adhesion-dependent cell spreading |
GO_0070507 | Biological process | regulation of microtubule cytoskeleton organization |
GO_0048672 | Biological process | positive regulation of collateral sprouting |
GO_0031290 | Biological process | retinal ganglion cell axon guidance |
GO_0051965 | Biological process | positive regulation of synapse assembly |
GO_0007399 | Biological process | nervous system development |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0007411 | Biological process | axon guidance |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0098982 | Cellular component | GABA-ergic synapse |
GO_0005912 | Cellular component | adherens junction |
GO_0005604 | Cellular component | basement membrane |
GO_0005901 | Cellular component | caveola |
GO_0046875 | Molecular function | ephrin receptor binding |
GO_0005169 | Molecular function | neurotrophin TRKB receptor binding |
GO_0005168 | Molecular function | neurotrophin TRKA receptor binding |
GO_0005170 | Molecular function | neurotrophin TRKC receptor binding |
GO_0045499 | Molecular function | chemorepellent activity |
GO_0030297 | Molecular function | transmembrane receptor protein tyrosine kinase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EFNA5 |
Protein name | Alternative protein EFNA5 Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7) EPH-related receptor tyrosine kinase ligand 7 |
Synonyms | LERK7 EPLG7 |
Description | FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. . |
Accessions | P52803 L8E7B5 D6RDV5 L8E8V0 ENST00000333274.11 ENST00000509503.1 |