Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 23 studies | 24% ± 10% | |
| conventional dendritic cell | 17 studies | 34% ± 15% | |
| macrophage | 16 studies | 30% ± 10% | |
| memory B cell | 15 studies | 24% ± 6% | |
| naive B cell | 11 studies | 21% ± 3% | |
| dendritic cell | 8 studies | 26% ± 8% | |
| plasma cell | 5 studies | 30% ± 7% | |
| myeloid cell | 4 studies | 24% ± 6% | |
| endothelial cell of sinusoid | 4 studies | 26% ± 8% | |
| mononuclear phagocyte | 3 studies | 32% ± 3% | |
| monocyte | 3 studies | 31% ± 6% |
Insufficient scRNA-seq data for expression of FCGR2B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 97% | 544.71 | 563 / 578 | 92% | 6.15 | 1057 / 1155 |
| breast | 88% | 413.30 | 405 / 459 | 95% | 4.76 | 1057 / 1118 |
| bladder | 90% | 279.52 | 19 / 21 | 62% | 2.76 | 313 / 504 |
| skin | 61% | 155.53 | 1098 / 1809 | 90% | 6.03 | 427 / 472 |
| thymus | 77% | 237.65 | 506 / 653 | 70% | 2.26 | 424 / 605 |
| intestine | 97% | 539.79 | 934 / 966 | 50% | 1.79 | 266 / 527 |
| esophagus | 86% | 333.71 | 1245 / 1445 | 56% | 1.71 | 103 / 183 |
| kidney | 54% | 179.37 | 48 / 89 | 82% | 5.05 | 740 / 901 |
| liver | 92% | 488.19 | 208 / 226 | 42% | 2.17 | 169 / 406 |
| uterus | 53% | 96.07 | 90 / 170 | 70% | 2.20 | 322 / 459 |
| stomach | 54% | 142.79 | 193 / 359 | 62% | 1.99 | 177 / 286 |
| ovary | 29% | 65.16 | 53 / 180 | 84% | 4.63 | 361 / 430 |
| adrenal gland | 81% | 247.45 | 208 / 258 | 26% | 0.60 | 60 / 230 |
| spleen | 100% | 1605.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 11% | 17.95 | 37 / 328 | 88% | 4.91 | 157 / 178 |
| adipose | 99% | 1034.93 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 1039.06 | 916 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 11.03 | 28 / 29 |
| prostate | 47% | 93.24 | 116 / 245 | 35% | 0.67 | 174 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 3.34 | 35 / 45 |
| blood vessel | 78% | 305.93 | 1038 / 1335 | 0% | 0 | 0 / 0 |
| heart | 69% | 184.76 | 595 / 861 | 0% | 0 | 0 / 0 |
| brain | 11% | 25.93 | 279 / 2642 | 33% | 2.19 | 235 / 705 |
| muscle | 21% | 35.12 | 171 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 14% | 0.24 | 11 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050766 | Biological process | positive regulation of phagocytosis |
| GO_0043031 | Biological process | negative regulation of macrophage activation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0010469 | Biological process | regulation of signaling receptor activity |
| GO_0006898 | Biological process | receptor-mediated endocytosis |
| GO_0002313 | Biological process | mature B cell differentiation involved in immune response |
| GO_0050859 | Biological process | negative regulation of B cell receptor signaling pathway |
| GO_0090264 | Biological process | regulation of immune complex clearance by monocytes and macrophages |
| GO_0009617 | Biological process | response to bacterium |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0001811 | Biological process | negative regulation of type I hypersensitivity |
| GO_0071219 | Biological process | cellular response to molecule of bacterial origin |
| GO_1902564 | Biological process | negative regulation of neutrophil activation |
| GO_0050777 | Biological process | negative regulation of immune response |
| GO_0038094 | Biological process | Fc-gamma receptor signaling pathway |
| GO_0043318 | Biological process | negative regulation of cytotoxic T cell degranulation |
| GO_2001199 | Biological process | negative regulation of dendritic cell differentiation |
| GO_0006911 | Biological process | phagocytosis, engulfment |
| GO_0002819 | Biological process | regulation of adaptive immune response |
| GO_0032693 | Biological process | negative regulation of interleukin-10 production |
| GO_0002252 | Biological process | immune effector process |
| GO_0002922 | Biological process | positive regulation of humoral immune response |
| GO_0045088 | Biological process | regulation of innate immune response |
| GO_0002865 | Biological process | negative regulation of acute inflammatory response to antigenic stimulus |
| GO_0002638 | Biological process | negative regulation of immunoglobulin production |
| GO_0050765 | Biological process | negative regulation of phagocytosis |
| GO_0002316 | Biological process | follicular B cell differentiation |
| GO_0002924 | Biological process | negative regulation of humoral immune response mediated by circulating immunoglobulin |
| GO_0001788 | Biological process | antibody-dependent cellular cytotoxicity |
| GO_0016064 | Biological process | immunoglobulin mediated immune response |
| GO_1902950 | Biological process | regulation of dendritic spine maintenance |
| GO_1903381 | Biological process | regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway |
| GO_0006909 | Biological process | phagocytosis |
| GO_0001814 | Biological process | negative regulation of antibody-dependent cellular cytotoxicity |
| GO_0001818 | Biological process | negative regulation of cytokine production |
| GO_0021549 | Biological process | cerebellum development |
| GO_0019886 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO_0002605 | Biological process | negative regulation of dendritic cell antigen processing and presentation |
| GO_1905898 | Biological process | positive regulation of response to endoplasmic reticulum stress |
| GO_0002436 | Biological process | immune complex clearance by monocytes and macrophages |
| GO_0002266 | Biological process | follicular dendritic cell activation |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0002622 | Biological process | regulation of B cell antigen processing and presentation |
| GO_0030889 | Biological process | negative regulation of B cell proliferation |
| GO_0045576 | Biological process | mast cell activation |
| GO_0006952 | Biological process | defense response |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0050869 | Biological process | negative regulation of B cell activation |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0044297 | Cellular component | cell body |
| GO_0019772 | Molecular function | low-affinity IgG receptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0019770 | Molecular function | IgG receptor activity |
| GO_0019864 | Molecular function | IgG binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FCGR2B |
| Protein name | Fc-gamma-receptor IIB Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32) Fc gamma receptor IIB |
| Synonyms | IGFR2 FCG2 CD32 |
| Description | FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Accessions | ENST00000236937.13 [P31994-2] Q8NIA0 Q8IZV7 ENST00000367961.8 [P31994-3] Q8NI89 P31994 ENST00000358671.10 [P31994-1] |
