Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 9 studies | 30% ± 12% | |
| fibroblast | 6 studies | 23% ± 6% | |
| adipocyte | 5 studies | 21% ± 6% | |
| neuron | 4 studies | 37% ± 18% | |
| connective tissue cell | 3 studies | 31% ± 7% | |
| GABAergic neuron | 3 studies | 22% ± 5% |
Insufficient scRNA-seq data for expression of CNTFR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 4960.34 | 2585 / 2642 | 99% | 128.29 | 695 / 705 |
| breast | 99% | 4566.15 | 454 / 459 | 33% | 9.19 | 368 / 1118 |
| thymus | 81% | 1306.09 | 528 / 653 | 28% | 23.66 | 169 / 605 |
| spleen | 99% | 2841.20 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 4766.94 | 1193 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 6879.25 | 792 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 32.22 | 73 / 80 |
| skin | 48% | 568.08 | 865 / 1809 | 23% | 9.03 | 107 / 472 |
| prostate | 49% | 894.93 | 121 / 245 | 18% | 2.14 | 91 / 502 |
| liver | 37% | 364.67 | 83 / 226 | 29% | 9.16 | 118 / 406 |
| ovary | 19% | 276.84 | 35 / 180 | 46% | 23.92 | 198 / 430 |
| uterus | 35% | 548.06 | 59 / 170 | 30% | 13.51 | 138 / 459 |
| adrenal gland | 18% | 179.91 | 46 / 258 | 46% | 37.55 | 105 / 230 |
| intestine | 46% | 495.22 | 442 / 966 | 9% | 1.87 | 48 / 527 |
| blood vessel | 49% | 824.57 | 657 / 1335 | 0% | 0 | 0 / 0 |
| heart | 48% | 1322.81 | 417 / 861 | 0% | 0 | 0 / 0 |
| stomach | 29% | 320.31 | 104 / 359 | 19% | 5.67 | 53 / 286 |
| bladder | 33% | 315.52 | 7 / 21 | 9% | 2.74 | 46 / 504 |
| esophagus | 18% | 215.11 | 258 / 1445 | 11% | 2.81 | 21 / 183 |
| lung | 14% | 145.66 | 82 / 578 | 9% | 2.03 | 101 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 20% | 2.99 | 9 / 45 |
| pancreas | 0% | 2.60 | 1 / 328 | 14% | 2.13 | 25 / 178 |
| kidney | 8% | 89.93 | 7 / 89 | 5% | 1.71 | 43 / 901 |
| peripheral blood | 0% | 1.41 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007548 | Biological process | sex differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0070120 | Biological process | ciliary neurotrophic factor-mediated signaling pathway |
| GO_0003360 | Biological process | brainstem development |
| GO_2000672 | Biological process | negative regulation of motor neuron apoptotic process |
| GO_0097049 | Biological process | motor neuron apoptotic process |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0060538 | Biological process | skeletal muscle organ development |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0007399 | Biological process | nervous system development |
| GO_0001967 | Biological process | suckling behavior |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0019898 | Cellular component | extrinsic component of membrane |
| GO_0070110 | Cellular component | ciliary neurotrophic factor receptor complex |
| GO_0097059 | Cellular component | CNTFR-CLCF1 complex |
| GO_0004897 | Molecular function | ciliary neurotrophic factor receptor activity |
| GO_0019955 | Molecular function | cytokine binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CNTFR |
| Protein name | Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha) Ciliary neurotrophic factor receptor subunit alpha |
| Synonyms | |
| Description | FUNCTION: Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 . Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1 . . |
| Accessions | ENST00000378980.8 ENST00000417345.2 ENST00000351266.8 A0A0A0N0N2 ENST00000610543.4 P26992 Q5T8H6 |
