MS4A2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MS4A2 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0007166Biological processcell surface receptor signaling pathway
GO_0032998Cellular componentFc-epsilon receptor I complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding
GO_0019863Molecular functionIgE binding

IV. Literature review

[source]
Gene nameMS4A2
Protein nameMembrane spanning 4-domains A2
High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)
SynonymsFCER1B
APY
IGER
DescriptionFUNCTION: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

AccessionsENST00000278888.8
Q01362
ENST00000524868.1
E9PLJ1
ENST00000617306.1
A0A0B4J2E9