ITGA9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045906Biological processnegative regulation of vasoconstriction
GO_0030593Biological processneutrophil chemotaxis
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0033627Biological processcell adhesion mediated by integrin
GO_0007155Biological processcell adhesion
GO_0098609Biological processcell-cell adhesion
GO_0007160Biological processcell-matrix adhesion
GO_0034679Cellular componentintegrin alpha9-beta1 complex
GO_0008305Cellular componentintegrin complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0098640Molecular functionintegrin binding involved in cell-matrix adhesion
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameITGA9
Protein nameIntegrin alpha-9 (Integrin alpha-RLC)
Alternative protein ITGA9
Integrin subunit alpha 9
Synonyms
DescriptionFUNCTION: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction . .

AccessionsENST00000707666.1
ENST00000422441.5
Q13797
H7C2L1
E9PDS3
ENST00000264741.10
L8E7C7
ENST00000411817.2