ABCA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0071300Biological processcellular response to retinoic acid
GO_0055091Biological processphospholipid homeostasis
GO_0042158Biological processlipoprotein biosynthetic process
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0008203Biological processcholesterol metabolic process
GO_0043691Biological processreverse cholesterol transport
GO_0032367Biological processintracellular cholesterol transport
GO_0032489Biological processregulation of Cdc42 protein signal transduction
GO_0099039Biological processsphingolipid translocation
GO_0002790Biological processpeptide secretion
GO_0033552Biological processresponse to vitamin B3
GO_0033700Biological processphospholipid efflux
GO_0006911Biological processphagocytosis, engulfment
GO_0023061Biological processsignal release
GO_0042632Biological processcholesterol homeostasis
GO_0140115Biological processexport across plasma membrane
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0071345Biological processcellular response to cytokine stimulus
GO_0016197Biological processendosomal transport
GO_0034380Biological processhigh-density lipoprotein particle assembly
GO_0060155Biological processplatelet dense granule organization
GO_0038027Biological processapolipoprotein A-I-mediated signaling pathway
GO_0090108Biological processpositive regulation of high-density lipoprotein particle assembly
GO_0071397Biological processcellular response to cholesterol
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0045332Biological processphospholipid translocation
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0033344Biological processcholesterol efflux
GO_0090107Biological processregulation of high-density lipoprotein particle assembly
GO_0034616Biological processresponse to laminar fluid shear stress
GO_0071806Biological processprotein transmembrane transport
GO_0009306Biological processprotein secretion
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0097708Cellular componentintracellular vesicle
GO_0045335Cellular componentphagocytic vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005768Cellular componentendosome
GO_0016323Cellular componentbasolateral plasma membrane
GO_0034188Molecular functionapolipoprotein A-I receptor activity
GO_0090554Molecular functionphosphatidylcholine floppase activity
GO_0090556Molecular functionphosphatidylserine floppase activity
GO_0019905Molecular functionsyntaxin binding
GO_0140359Molecular functionABC-type transporter activity
GO_0015485Molecular functioncholesterol binding
GO_0046623Molecular functionsphingolipid floppase activity
GO_0120020Molecular functioncholesterol transfer activity
GO_0005102Molecular functionsignaling receptor binding
GO_0031267Molecular functionsmall GTPase binding
GO_0034185Molecular functionapolipoprotein binding
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0031210Molecular functionphosphatidylcholine binding
GO_0005548Molecular functionphospholipid transporter activity
GO_0140328Molecular functionfloppase activity
GO_0005524Molecular functionATP binding
GO_0051117Molecular functionATPase binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0034186Molecular functionapolipoprotein A-I binding
GO_0008035Molecular functionhigh-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCA1
Protein namePhospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
ATP-binding cassette, sub-family A (ABC1), member 1
Alternative protein ABCA1
ATP-binding cassette transporter A1
ABCA1 protein
ATP binding cassette transporter 1
ATP binding cassette subfamily A member 1
ATP binding cassette subfamily A member 1 (ATP-binding cassette, sub-family A (ABC1), member 1, isoform CRA_b)
SynonymsCERP
hCG_1789838
ABC1
DescriptionFUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP . Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs . Transports preferentially phosphatidylcholine over phosphatidylserine . May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs . Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain . .

AccessionsB2RUU2
ENST00000423487.6
ENST00000374736.8
A5D8U6
ENST00000374733.1
B1AMI1
ENST00000678995.1
A0A7I2V5U0
B7XCW9
O95477
L8E884
B1AMI2
Q9NP93