ITGB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	45 studies	65% ± 23%	Explore
macrophage	42 studies	56% ± 19%	Explore
CD8-positive, alpha-beta T cell	35 studies	48% ± 20%	Explore
CD4-positive, alpha-beta T cell	29 studies	42% ± 15%	Explore
T cell	28 studies	44% ± 17%	Explore
classical monocyte	28 studies	75% ± 16%	Explore
conventional dendritic cell	27 studies	75% ± 17%	Explore
regulatory T cell	26 studies	43% ± 17%	Explore
non-classical monocyte	25 studies	83% ± 13%	Explore
monocyte	24 studies	61% ± 20%	Explore
B cell	23 studies	28% ± 11%	Explore
dendritic cell	22 studies	63% ± 25%	Explore
mature NK T cell	21 studies	62% ± 19%	Explore
gamma-delta T cell	18 studies	53% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	70% ± 20%	Explore
mucosal invariant T cell	16 studies	46% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	36% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	78% ± 23%	Explore
myeloid cell	16 studies	57% ± 20%	Explore
memory B cell	14 studies	26% ± 8%	Explore
naive B cell	14 studies	27% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	44% ± 17%	Explore
plasmacytoid dendritic cell	13 studies	38% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	53% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	45% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	49% ± 20%	Explore
neutrophil	12 studies	45% ± 20%	Explore
leukocyte	10 studies	37% ± 12%	Explore
microglial cell	10 studies	38% ± 22%	Explore
alveolar macrophage	7 studies	46% ± 13%	Explore
innate lymphoid cell	7 studies	46% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	57% ± 25%	Explore
mononuclear phagocyte	7 studies	53% ± 25%	Explore
T follicular helper cell	7 studies	41% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	65% ± 16%	Explore
exhausted T cell	5 studies	69% ± 12%	Explore
plasmablast	5 studies	35% ± 14%	Explore
platelet	5 studies	36% ± 18%	Explore
hematopoietic precursor cell	5 studies	46% ± 14%	Explore
plasma cell	5 studies	28% ± 7%	Explore
double negative thymocyte	5 studies	60% ± 20%	Explore
intermediate monocyte	5 studies	77% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	50% ± 14%	Explore
CD4-positive helper T cell	4 studies	22% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	68% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	53% ± 18%	Explore
lymphocyte	4 studies	35% ± 19%	Explore
immature B cell	4 studies	28% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	69% ± 11%	Explore
monocyte-derived dendritic cell	3 studies	65% ± 27%	Explore
common myeloid progenitor	3 studies	34% ± 5%	Explore
hematopoietic stem cell	3 studies	27% ± 10%	Explore
T-helper 17 cell	3 studies	46% ± 16%	Explore
precursor B cell	3 studies	26% ± 6%	Explore
tissue-resident macrophage	3 studies	52% ± 20%	Explore
germinal center B cell	3 studies	24% ± 6%	Explore
inflammatory macrophage	3 studies	53% ± 11%	Explore
T-helper 1 cell	3 studies	48% ± 24%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	48% ± 20%	Explore
erythrocyte	3 studies	36% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	57% ± 15%	Explore
lung	9 studies	29% ± 8%	Explore
bone marrow	5 studies	37% ± 26%	Explore
lymph node	4 studies	39% ± 14%	Explore
liver	4 studies	32% ± 16%	Explore
brain	3 studies	40% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	10626.90	576 / 578	91%	73.18	1055 / 1155
breast	79%	2373.96	363 / 459	91%	49.54	1020 / 1118
intestine	77%	2249.96	745 / 966	67%	29.99	355 / 527
bladder	81%	1660.29	17 / 21	62%	33.56	312 / 504
kidney	37%	1077.03	33 / 89	88%	63.41	796 / 901
thymus	45%	1011.16	294 / 653	79%	46.13	480 / 605
stomach	49%	1122.57	175 / 359	72%	31.79	206 / 286
uterus	42%	773.04	72 / 170	77%	32.27	355 / 459
brain	32%	736.33	835 / 2642	87%	56.00	614 / 705
skin	37%	559.44	668 / 1809	81%	64.23	384 / 472
adrenal gland	82%	2440.83	211 / 258	30%	7.84	68 / 230
pancreas	23%	484.44	75 / 328	88%	62.49	157 / 178
ovary	33%	620.37	59 / 180	77%	32.21	331 / 430
prostate	52%	998.40	128 / 245	57%	14.06	287 / 502
esophagus	45%	965.30	656 / 1445	58%	17.25	107 / 183
lymph node	0%	0	0 / 0	100%	330.83	29 / 29
peripheral blood	100%	62036.80	929 / 929	0%	0	0 / 0
spleen	100%	22491.00	241 / 241	0%	0	0 / 0
adipose	95%	5569.20	1145 / 1204	0%	0	0 / 0
liver	42%	781.46	95 / 226	50%	17.48	202 / 406
tonsil	0%	0	0 / 0	91%	65.07	41 / 45
blood vessel	70%	2773.54	937 / 1335	0%	0	0 / 0
heart	33%	690.34	287 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	33%	9.91	26 / 80
muscle	3%	36.15	22 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1990266	Biological process	neutrophil migration
GO_0098742	Biological process	cell-cell adhesion via plasma-membrane adhesion molecules
GO_0031623	Biological process	receptor internalization
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0006954	Biological process	inflammatory response
GO_0001774	Biological process	microglial cell activation
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0007160	Biological process	cell-matrix adhesion
GO_0030593	Biological process	neutrophil chemotaxis
GO_0035987	Biological process	endodermal cell differentiation
GO_0007155	Biological process	cell adhesion
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_0006911	Biological process	phagocytosis, engulfment
GO_0007267	Biological process	cell-cell signaling
GO_0043315	Biological process	positive regulation of neutrophil degranulation
GO_0097242	Biological process	amyloid-beta clearance
GO_0043113	Biological process	receptor clustering
GO_0045963	Biological process	negative regulation of dopamine metabolic process
GO_0050730	Biological process	regulation of peptidyl-tyrosine phosphorylation
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0090314	Biological process	positive regulation of protein targeting to membrane
GO_0006915	Biological process	apoptotic process
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0008360	Biological process	regulation of cell shape
GO_1904996	Biological process	positive regulation of leukocyte adhesion to vascular endothelial cell
GO_0098609	Biological process	cell-cell adhesion
GO_2000363	Biological process	positive regulation of prostaglandin-E synthase activity
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0008305	Cellular component	integrin complex
GO_0034687	Cellular component	integrin alphaL-beta2 complex
GO_0034689	Cellular component	integrin alphaX-beta2 complex
GO_1903561	Cellular component	extracellular vesicle
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0044853	Cellular component	plasma membrane raft
GO_0070821	Cellular component	tertiary granule membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0034688	Cellular component	integrin alphaM-beta2 complex
GO_0031072	Molecular function	heat shock protein binding
GO_0038024	Molecular function	cargo receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0019901	Molecular function	protein kinase binding
GO_0005178	Molecular function	integrin binding
GO_0046872	Molecular function	metal ion binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0001851	Molecular function	complement component C3b binding
GO_0005515	Molecular function	protein binding
GO_0030369	Molecular function	ICAM-3 receptor activity

IV. Literature review

[source]

Gene name	ITGB2
Protein name	Integrin beta Integrin beta-2 Integrin beta-2 (Integrin subunit beta 2) Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) Integrin subunit beta 2
Synonyms	CD18 MFI7 hCG_401305
Description	FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL . Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity . Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils . Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation . Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages . In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils . .
Accessions	D3DSM0 ENST00000521995.1 ENST00000397852.5 A0A891XJL9 ENST00000320216.10 A0A024DAE5 A0A891XIL1 A0A891XIN2 ENST00000522931.5 A0A891XJG5 ENST00000520389.5 A0A891XJI7 ENST00000517819.5 P05107 A0A8E8U5C4 ENST00000522688.5 A0A891XKA1 ENST00000355153.8 E5RGK9 A0A024D9S0 E5RFI0 E5RHT0 A0A494C0X7 E5RK25 A0A024DBG3 ENST00000517563.5 E5RIE4 A0A891XK94 Q96PT7 A0A024DAT2 A0A891XJI0 A8MVG7 ENST00000397857.5 E7EVZ9 E5RHE6 A0A024DAF4 A0A891XIG5 A0A891XIT7 A0A024DAS2 A0A8E8U565 ENST00000524251.1 ENST00000652462.1 A0A8E8PH05 A0A024DBF0 A0A024DBF8 A0A891XIU9 E5RK54 ENST00000397854.7 ENST00000523663.5 A0A891XIU5 ENST00000397846.7 ENST00000523323.5 A0A891XJM2 J3KNI6 A0A024DAS5 ENST00000397850.6 A0A891XJL7 A0A024D9P8 E5RIG7

ITGB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review