CD80 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CD80 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD80 at tissue level.

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0031295Biological processT cell costimulation
GO_0009967Biological processpositive regulation of signal transduction
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0006955Biological processimmune response
GO_0046718Biological processsymbiont entry into host cell
GO_0035556Biological processintracellular signal transduction
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0002710Biological processnegative regulation of T cell mediated immunity
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0045627Biological processpositive regulation of T-helper 1 cell differentiation
GO_0042110Biological processT cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009986Cellular componentcell surface
GO_0098636Cellular componentprotein complex involved in cell adhesion
GO_0015026Molecular functioncoreceptor activity
GO_0048018Molecular functionreceptor ligand activity
GO_0001618Molecular functionvirus receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD80
Protein nameT-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), isoform CRA_a (CD80 molecule) (cDNA FLJ75225, highly similar to Homo sapiens CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (CD80), mRNA)
SynonymsLAB7
CD28LG
CD28LG1
hCG_1780136
DescriptionFUNCTION: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. .; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. .

AccessionsENST00000264246.8 [P33681-1]
A0N0P2
P33681
ENST00000383669.3 [P33681-2]
ENST00000478182.5 [P33681-1]