Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| regulatory T cell | 9 studies | 21% ± 5% | |
| B cell | 7 studies | 21% ± 4% | |
| mucosal invariant T cell | 7 studies | 28% ± 8% | |
| memory B cell | 6 studies | 21% ± 4% | |
| naive B cell | 6 studies | 23% ± 5% | |
| CD4-positive, alpha-beta T cell | 5 studies | 20% ± 3% | |
| innate lymphoid cell | 3 studies | 23% ± 6% | |
| group 3 innate lymphoid cell | 3 studies | 23% ± 7% | |
| T-helper 17 cell | 3 studies | 32% ± 1% |
Insufficient scRNA-seq data for expression of CCR6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| spleen | 100% | 1686.59 | 241 / 241 | 0% | 0 | 0 / 0 |
| thymus | 99% | 109.05 | 645 / 653 | 0% | 0 | 0 / 605 |
| kidney | 97% | 89.28 | 86 / 89 | 1% | 0.01 | 7 / 901 |
| lung | 97% | 100.59 | 558 / 578 | 0% | 0.00 | 2 / 1155 |
| peripheral blood | 96% | 769.01 | 894 / 929 | 0% | 0 | 0 / 0 |
| prostate | 85% | 48.56 | 209 / 245 | 0% | 0 | 0 / 502 |
| intestine | 82% | 287.33 | 796 / 966 | 0% | 0.01 | 2 / 527 |
| stomach | 81% | 55.16 | 290 / 359 | 0% | 0.00 | 1 / 286 |
| brain | 78% | 58.06 | 2067 / 2642 | 0% | 0 | 0 / 705 |
| liver | 77% | 33.65 | 175 / 226 | 0% | 0.00 | 1 / 406 |
| breast | 70% | 38.57 | 322 / 459 | 2% | 0.03 | 18 / 1118 |
| adipose | 71% | 31.70 | 849 / 1204 | 0% | 0 | 0 / 0 |
| skin | 65% | 40.68 | 1182 / 1809 | 1% | 0.01 | 4 / 472 |
| bladder | 62% | 36.29 | 13 / 21 | 0% | 0 | 0 / 504 |
| esophagus | 60% | 39.36 | 874 / 1445 | 0% | 0 | 0 / 183 |
| ovary | 60% | 19.96 | 108 / 180 | 0% | 0 | 0 / 430 |
| adrenal gland | 59% | 19.02 | 152 / 258 | 0% | 0 | 0 / 230 |
| blood vessel | 46% | 19.69 | 618 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 38% | 13.58 | 64 / 170 | 0% | 0 | 0 / 459 |
| pancreas | 35% | 9.86 | 116 / 328 | 2% | 0.02 | 3 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.23 | 3 / 29 |
| heart | 8% | 2.58 | 65 / 861 | 0% | 0 | 0 / 0 |
| muscle | 1% | 0.29 | 7 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0072676 | Biological process | lymphocyte migration |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_1904156 | Biological process | DN3 thymocyte differentiation |
| GO_1904155 | Biological process | DN2 thymocyte differentiation |
| GO_0060474 | Biological process | positive regulation of flagellated sperm motility involved in capacitation |
| GO_0007165 | Biological process | signal transduction |
| GO_0002523 | Biological process | leukocyte migration involved in inflammatory response |
| GO_0006935 | Biological process | chemotaxis |
| GO_0006968 | Biological process | cellular defense response |
| GO_0006959 | Biological process | humoral immune response |
| GO_0048290 | Biological process | isotype switching to IgA isotypes |
| GO_0006955 | Biological process | immune response |
| GO_2000510 | Biological process | positive regulation of dendritic cell chemotaxis |
| GO_0072679 | Biological process | thymocyte migration |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0072678 | Biological process | T cell migration |
| GO_2000404 | Biological process | regulation of T cell migration |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0097524 | Cellular component | sperm plasma membrane |
| GO_0036126 | Cellular component | sperm flagellum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0097228 | Cellular component | sperm principal piece |
| GO_0097225 | Cellular component | sperm midpiece |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0004950 | Molecular function | chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCR6 |
| Protein name | C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196) |
| Synonyms | CMKBR6 GPR29 STRL22 CKRL3 |
| Description | FUNCTION: Receptor for the C-C type chemokine CCL20 . Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels . Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins . Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity . Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects . The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma . CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 . . |
| Accessions | P51684 ENST00000349984.6 ENST00000400926.5 ENST00000341935.10 ENST00000643861.1 |
