IL3RA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0038156Biological processinterleukin-3-mediated signaling pathway
GO_0036016Biological processcellular response to interleukin-3
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0019955Molecular functioncytokine binding
GO_0005515Molecular functionprotein binding
GO_0004896Molecular functioncytokine receptor activity
GO_0004912Molecular functioninterleukin-3 receptor activity

IV. Literature review

[source]
Gene nameIL3RA
Protein nameInterleukin 3 receptor subunit alpha
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
SynonymsIL3R
DescriptionFUNCTION: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells . Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). .

AccessionsENST00000432757.6
P26951
ENST00000381469.7 [P26951-2]
J3JS34
ENST00000711219.1 [P26951-1]
ENST00000331035.10 [P26951-1]
ENST00000711217.1 [P26951-2]
ENST00000711218.1